Aphthovirus internal ribosome entry site (IRES)

This family represents the internal ribosome entry site (IRES) of the Picornaviruses.^[1] IRES elements allow cap and end-independent translation of mRNA in the host cell. The IRES achieves this by mediating the internal initiation of translation by recruiting a ribosomal 43S pre-initiation complex directly to the initiation codon and eliminates the requirement for the eukaryotic initiation factor eIF4F.^[2]

Aphthovirus internal ribosome entry site (IRES)
Predicted secondary structure and sequence conservation of IRES_Aptho
Identifiers
Symbol	IRES_Aptho
Alt. Symbols	Aptho_IRES
Rfam	RF00210
Other data
RNA type	Cis-reg; IRES
Domain	Viruses
GO	GO:0043022
SO	SO:0000243
PDB structures	PDBe