Archaeosine synthase

Archaeosine synthase (EC 2.6.1.97, ArcS, TgtA2, MJ1022 (gene), glutamine:preQ0-tRNA amidinotransferase) is an enzyme with systematic name L-glutamine:7-cyano-7-carbaguanine aminotransferase.^[1][2] This enzyme catalyses the following chemical reaction

L-glutamine + 7-cyano-7-carbaguanine15 in tRNA + H2O ${\displaystyle \rightleftharpoons }$ L-glutamate + archaeine¹⁵ in tRNA

Archaeosine synthase
Identifiers
EC no.	2.6.1.97
Databases
IntEnz	IntEnz view
BRENDA	BRENDA entry
ExPASy	NiceZyme view
KEGG	KEGG entry
MetaCyc	metabolic pathway
PRIAM	profile
PDB structures	RCSB PDB PDBe PDBsum
Search PMC articles PubMed articles NCBI proteins

In Euryarchaeota the reaction is catalysed by ArcS.