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Arias-Stella reaction
From Wikipedia, the free encyclopedia
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Arias-Stella reaction, also Arias-Stella phenomenon, is a benign change in the endometrium associated with the presence of chorionic tissue.[1]
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Arias-Stella reaction is due to progesterone primarily. Cytologically, it resembles a malignancy and, historically, it was misdiagnosed as endometrial cancer.[1]
Significance
It is significant only because it can be misdiagnosed as a cancer. It may be seen in a completely normal pregnancy.
Diagnosis
It is characterized by nuclear enlargement and may also have any of the following: an irregular nuclear membrane, granular chromatin, centronuclear vacuolization, and pseudonuclear inclusions.[1]
Five subtypes are recognized:[1]
- Minimal atypia.
- Early secretory pattern.
- Secretory or hypersecretory pattern.
- Regenerative, proliferative or nonsecretory pattern.
- Monstrous cell pattern.
History
It was first described by Javier Arias Stella, a Peruvian pathologist, in 1954.[2]
See also
Molar ectopic
References
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