Atrolysin C

Atrolysin C (EC 3.4.24.42, Crotalus atrox metalloendopeptidase c, hemorrhagic toxin c and d) is an enzyme.^{[1][2][3][4][5][6]} This enzyme catalyses the following chemical reaction

Cleavage of His⁵-Leu, His¹⁰-Leu, Ala¹⁴-Leu, Tyr¹⁶-Leu and Gly²³-Phe bonds in B chain of insulin. With small molecule substrates prefers hydrophobic residue at P2' and small residue such as Ala, Gly at P1

Atrolysin C
Identifiers
EC no.	3.4.24.42
CAS no.	158886-17-0
Databases
IntEnz	IntEnz view
BRENDA	BRENDA entry
ExPASy	NiceZyme view
KEGG	KEGG entry
MetaCyc	metabolic pathway
PRIAM	profile
PDB structures	RCSB PDB PDBe PDBsum
Search PMC articles PubMed articles NCBI proteins

This endopeptidase is present in the venom of the western diamondback rattlesnake (Crotalus atrox).