Atrolysin E

Atrolysin E (EC 3.4.24.44, Crotalus atrox metalloendopeptidase e, hemorrhagic toxin e) is an enzyme.^[1][2][3] This enzyme catalyses the following chemical reaction

Cleavage of Asn³-Gln, Ser⁹-His and Ala¹⁴-Leu bonds in insulin B chain and Tyr¹⁴-Gln and Thr⁸-Ser in A chain. Cleaves type IV collagen at Ala⁷³-Gln in alpha1(IV) and at Gly⁷-Leu in alpha2(IV)

Atrolysin E
Identifiers
EC no.	3.4.24.44
CAS no.	172306-51-3
Databases
IntEnz	IntEnz view
BRENDA	BRENDA entry
ExPASy	NiceZyme view
KEGG	KEGG entry
MetaCyc	metabolic pathway
PRIAM	profile
PDB structures	RCSB PDB PDBe PDBsum
Search PMC articles PubMed articles NCBI proteins

This endopeptidase is present in the venom of the western diamondback rattlesnake (Crotalus atrox).