VTCN1

V-set domain-containing T-cell activation inhibitor 1 is a protein that in humans is encoded by the VTCN1 gene.^[5][6][7]

VTCN1
Available structures PDB Ortholog search: PDBe RCSB List of PDB id codes 4GOS
Identifiers
Aliases	VTCN1, B7-H4, B7H4, B7S1, B7X, B7h.5, PRO1291, VCTN1, V-set domain containing T cell activation inhibitor 1, V-set domain containing T-cell activation inhibitor 1
External IDs	OMIM: 608162; MGI: 3039619; HomoloGene: 11627; GeneCards: VTCN1; OMA:VTCN1 - orthologs
Gene location (Human) Chr. Chromosome 1 (human)[1] Band 1p13.1-p12 Start 117,143,587 bp[1] End 117,210,960 bp[1]
Gene location (Mouse) Chr. Chromosome 3 (mouse)[2] Band 3|3 F2.2 Start 100,732,775 bp[2] End 100,804,238 bp[2]
RNA expression pattern Bgee Human Mouse (ortholog) Top expressed in palpebral conjunctiva epithelium of lactiferous gland lactiferous duct hair follicle right uterine tube islet of Langerhans nasal epithelium body of pancreas olfactory zone of nasal mucosa secondary oocyte Top expressed in blastocyst morula spermatid uterus lip ascending aorta aortic valve cervix esophagus proximal tubule More reference expression data BioGPS More reference expression data
Gene ontology Molecular function signaling receptor binding molecular function Cellular component integral component of membrane plasma membrane membrane external side of plasma membrane Biological process adaptive immune response positive regulation of T cell proliferation response to protozoan immune system process negative regulation of T cell proliferation negative regulation of apoptotic process negative regulation of T cell activation regulation of immune response T cell receptor signaling pathway Sources:Amigo / QuickGO
Orthologs Species Human Mouse Entrez 79679 242122 Ensembl ENSG00000134258 ENSMUSG00000051076 UniProt Q7Z7D3 Q7TSP5 RefSeq (mRNA) NM_001253849 NM_001253850 NM_024626 NM_178594 RefSeq (protein) NP_001240778 NP_001240779 NP_078902 NP_848709 Location (UCSC) Chr 1: 117.14 – 117.21 Mb Chr 3: 100.73 – 100.8 Mb PubMed search [3] [4]
Wikidata
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Function

B7H4 belongs to the B7 family (see CD80; MIM 112203) of costimulatory proteins. These proteins are expressed on the surface of antigen-presenting cells and interact with ligands (e.g., CD28; MIM 186760) on T lymphocytes.[supplied by OMIM]^[7]

B7-H4 is an immune checkpoint molecule.

See also

• B7 (protein)