BRISC and BRCA1-A complex member 2

BRISC and BRCA1-A complex member 2 is a protein in humans encoded by the BABAM2 gene.

BABAM2
Identifiers
Aliases	BABAM2, BRCC4, BRCC45, BRE, brain and reproductive organ-expressed (TNFRSF1A modulator), BRISC and BRCA1 A complex member 2
External IDs	OMIM: 610497; MGI: 1333875; HomoloGene: 3604; GeneCards: BABAM2; OMA:BABAM2 - orthologs
Gene location (Human) Chr. Chromosome 2 (human)[1] Band 2p23.2 Start 27,889,941 bp[1] End 28,338,901 bp[1]
Gene location (Mouse) Chr. Chromosome 5 (mouse)[2] Band 5|5 B1 Start 31,855,028 bp[2] End 32,242,306 bp[2]
RNA expression pattern Bgee Human Mouse (ortholog) Top expressed in right adrenal gland left adrenal cortex right adrenal cortex gastrocnemius muscle right auricle of heart popliteal artery tibial arteries left ventricle muscle of thigh anterior pituitary Top expressed in lens transitional epithelium of urinary bladder adrenal gland ankle brown adipose tissue granulocyte epithelium of lens left lobe of liver muscle of thigh epithelium of stomach More reference expression data BioGPS More reference expression data
Gene ontology Molecular function peroxisome targeting sequence binding polyubiquitin modification-dependent protein binding protein binding tumor necrosis factor receptor binding Cellular component nuclear ubiquitin ligase complex nucleoplasm nucleus cytoplasm cytosol BRCA1-A complex BRISC complex Biological process response to ionizing radiation positive regulation of DNA repair cell division protein K63-linked deubiquitination cell cycle double-strand break repair via nonhomologous end joining signal transduction apoptotic process DNA repair cellular response to DNA damage stimulus double-strand break repair protein deubiquitination negative regulation of apoptotic process mitotic G2 DNA damage checkpoint signaling chromatin organization Sources:Amigo / QuickGO
Orthologs Species Human Mouse Entrez 9577 107976 Ensembl ENSG00000158019 ENSMUSG00000052139 UniProt Q9NXR7 Q8K3W0 RefSeq (mRNA) NM_001261840 NM_001329112 NM_001329113 NM_001329114 NM_001329115 NM_004899 NM_199191 NM_199192 NM_199193 NM_199194 NM_144541 NM_181279 NM_181280 NM_181281 NM_181282 RefSeq (protein) NP_001248769 NP_001316041 NP_001316042 NP_001316043 NP_001316044 NP_004890 NP_954661 NP_954662 NP_954663 NP_954664 NP_653124 NP_851796 NP_851797 NP_851798 NP_851799 Location (UCSC) Chr 2: 27.89 – 28.34 Mb Chr 5: 31.86 – 32.24 Mb PubMed search [3] [4]
Wikidata
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