BACE1-AS

BACE1-AS, also known as BACE1 antisense RNA (non-protein coding), is a human gene at 11q23.3 encoding a long noncoding RNA molecule. It is transcribed from the opposite strand to BACE1 and is upregulated in patients with Alzheimer's disease.^[2] BACE1-AS regulates the expression of BACE1 by increasing BACE1 mRNA stability and generating additional BACE1 through a post-transcriptional feed-forward mechanism. By the same mechanism it also raises concentrations of beta amyloid, the main constituent of senile plaques. BACE1-AS concentrations are elevated in subjects with Alzheimer's disease and in amyloid precursor protein transgenic mice.

BACE1-AS
Identifiers
Aliases	BACE1-AS, BACE1 antisense RNA, BACE1-AS1, FJ573250, NCRNA00177
External IDs	OMIM: 614263; GeneCards: BACE1-AS; OMA:BACE1-AS - orthologs
Orthologs Species Human Mouse Entrez 100379571 n/a Ensembl ENSG00000278768 n/a UniProt n a n/a RefSeq (mRNA) n/a n/a RefSeq (protein) n/a n/a Location (UCSC) n/a n/a PubMed search [1] n/a
Wikidata
View/Edit Human

Knocking down BACE1-AS reduces amyloid production and plaque deposition.^[3]