Brain-specific angiogenesis inhibitor 1

Brain-specific angiogenesis inhibitor 1 is a protein that in humans is encoded by the BAI1 gene.^[5][6] It is a member of the adhesion-GPCR family of receptors.^[7]

ADGRB1
Identifiers
Aliases	ADGRB1, BAI1, GDAIF, adhesion G protein-coupled receptor B1
External IDs	OMIM: 602682; MGI: 1933736; HomoloGene: 1287; GeneCards: ADGRB1; OMA:ADGRB1 - orthologs
Gene location (Human) Chr. Chromosome 8 (human)[1] Band 8q24.3 Start 142,449,430 bp[1] End 142,545,009 bp[1]
Gene location (Mouse) Chr. Chromosome 15 (mouse)[2] Band 15|15 D3 Start 74,388,044 bp[2] End 74,461,314 bp[2]
RNA expression pattern Bgee Human Mouse (ortholog) Top expressed in right frontal lobe nucleus accumbens cingulate gyrus anterior cingulate cortex Amygdala Brodmann area 9 caudate nucleus putamen prefrontal cortex right hemisphere of cerebellum Top expressed in superior frontal gyrus primary visual cortex dentate gyrus of hippocampal formation granule cell entorhinal cortex perirhinal cortex ventricular zone neural layer of retina CA3 field cerebellar cortex nucleus of stria terminalis More reference expression data BioGPS More reference expression data
Gene ontology Molecular function G protein-coupled receptor activity signal transducer activity transmembrane signaling receptor activity lipopolysaccharide binding phosphatidylserine binding PDZ domain binding protein binding Cellular component integral component of membrane integral component of plasma membrane cell-cell junction membrane phagocytic cup extracellular space plasma membrane focal adhesion postsynaptic density dendrite perinuclear region of cytoplasm extracellular region cell junction cell projection dendritic spine synapse postsynaptic membrane Biological process G protein-coupled receptor signaling pathway cell surface receptor signaling pathway peripheral nervous system development axonogenesis signal transduction negative regulation of cell population proliferation positive regulation of synapse assembly phagocytosis, recognition phagocytosis, engulfment negative regulation of endothelial cell migration negative regulation of angiogenesis negative regulation of protein ubiquitination negative regulation of protein catabolic process apoptotic cell clearance engulfment of apoptotic cell regulation of synaptic plasticity defense response to Gram-negative bacterium positive regulation of myoblast fusion positive regulation of reactive oxygen species biosynthetic process immune system process phagocytosis cell adhesion nervous system development muscle organ development innate immune response adenylate cyclase-activating G protein-coupled receptor signaling pathway Sources:Amigo / QuickGO
Orthologs Species Human Mouse Entrez 575 107831 Ensembl ENSG00000181790 ENSMUSG00000034730 UniProt O14514 Q3UHD1 RefSeq (mRNA) NM_001702 NM_001391985 NM_001391986 NM_001391987 NM_001391988 NM_174991 NM_001359759 RefSeq (protein) NP_001693 NP_778156 NP_001346688 Location (UCSC) Chr 8: 142.45 – 142.55 Mb Chr 15: 74.39 – 74.46 Mb PubMed search [3] [4]
Wikidata
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Function

Angiogenesis is controlled by a local balance between stimulators and inhibitors of new vessel growth and is suppressed under normal physiologic conditions. Angiogenesis has been shown to be essential for growth and metastasis of solid tumors. In order to obtain blood supply for their growth, tumor cells are potently angiogenic and attract new vessels as results of increased secretion of inducers and decreased production of endogenous negative regulators. BAI1 contains at least one 'functional' p53-binding site within an intron, and its expression has been shown to be induced by wildtype p53. There are two other brain-specific angiogenesis inhibitor genes, designated BAI2 and BAI3 which along with BAI1 have similar tissue specificities and structures, however only BAI1 is transcriptionally regulated by p53. BAI1 is postulated to be a member of the secretin receptor family, an inhibitor of angiogenesis and a growth suppressor of glioblastomas.^[6]

Interactions

Brain-specific angiogenesis inhibitor 1 has been shown to interact with BAIAP3^[8] and MAGI1.^[9]