Tyrosine-protein kinase BLK

Tyrosine-protein kinase BLK, also known as B lymphocyte kinase, is a non-receptor tyrosine kinase that in humans is encoded by the BLK gene.^[5][6] It is of the Src family of tyrosine kinases.

BLK
Identifiers
Aliases	BLK, MODY11, BLK proto-oncogene, Src family tyrosine kinase
External IDs	OMIM: 191305; MGI: 88169; HomoloGene: 1297; GeneCards: BLK; OMA:BLK - orthologs
Gene location (Human) Chr. Chromosome 8 (human)[1] Band 8p23.1 Start 11,486,894 bp[1] End 11,564,599 bp[1]
Gene location (Mouse) Chr. Chromosome 14 (mouse)[2] Band 14 D1|14 33.25 cM Start 63,610,285 bp[2] End 63,654,486 bp[2]
RNA expression pattern Bgee Human Mouse (ortholog) Top expressed in spleen testicle lymph node granulocyte appendix mucosa of transverse colon bone marrow cell blood tonsil stromal cell of endometrium Top expressed in spleen mesenteric lymph nodes blood granulocyte thymus subcutaneous adipose tissue bone marrow Ileal epithelium axillary lymph node tunica adventitia of aorta More reference expression data BioGPS More reference expression data
Gene ontology Molecular function transferase activity nucleotide binding protein kinase activity non-membrane spanning protein tyrosine kinase activity kinase activity protein binding protein tyrosine kinase activity signaling receptor binding ATP binding Cellular component membrane extrinsic component of cytoplasmic side of plasma membrane plasma membrane cytosol Biological process B cell receptor signaling pathway cell differentiation intracellular signal transduction phosphorylation transmembrane receptor protein tyrosine kinase signaling pathway protein phosphorylation regulation of cell population proliferation peptidyl-tyrosine autophosphorylation innate immune response positive regulation of insulin secretion cell migration regulation of B cell receptor signaling pathway peptidyl-tyrosine phosphorylation Sources:Amigo / QuickGO
Orthologs Species Human Mouse Entrez 640 12143 Ensembl ENSG00000136573 ENSG00000285369 ENSMUSG00000014453 UniProt P51451 P16277 RefSeq (mRNA) NM_001715 NM_001330465 NM_007549 RefSeq (protein) NP_001317394 NP_001706 NP_031575 Location (UCSC) Chr 8: 11.49 – 11.56 Mb Chr 14: 63.61 – 63.65 Mb PubMed search [3] [4]
Wikidata
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Interactions

The tyrosine-protein kinase BLK has been shown to interact with UBE3A.^[7]