Bleomycin hydrolase

Bleomycin hydrolase is an enzyme that in humans is encoded by the BLMH gene.^[5][6][7]

BLMH
Available structures PDB Ortholog search: PDBe RCSB List of PDB id codes 1CB5, 2CB5
Identifiers
Aliases	BLMH, BH, BMH, bleomycin hydrolase
External IDs	OMIM: 602403; MGI: 1345186; HomoloGene: 330; GeneCards: BLMH; OMA:BLMH - orthologs
Gene location (Human) Chr. Chromosome 17 (human)[1] Band 17q11.2 Start 30,248,203 bp[1] End 30,292,056 bp[1]
Gene location (Mouse) Chr. Chromosome 11 (mouse)[2] Band 11|11 B5 Start 76,815,635 bp[2] End 76,878,205 bp[2]
RNA expression pattern Bgee Human Mouse (ortholog) Top expressed in skin of arm skin of leg skin of abdomen skin of thigh epithelium of colon body of pancreas Descending thoracic aorta mucosa of esophagus stromal cell of endometrium body of uterus Top expressed in fossa condyle primitive streak hair follicle renal corpuscle internal carotid artery esophagus vas deferens external carotid artery skin of abdomen More reference expression data BioGPS More reference expression data
Gene ontology Molecular function peptidase activity hydrolase activity carboxypeptidase activity cysteine-type endopeptidase activity protein binding cysteine-type peptidase activity aminopeptidase activity identical protein binding Cellular component extracellular exosome cytosol nucleus cytoplasm Biological process protein polyubiquitination proteolysis response to toxic substance homocysteine catabolic process Sources:Amigo / QuickGO
Orthologs Species Human Mouse Entrez 642 104184 Ensembl ENSG00000108578 ENSMUSG00000020840 UniProt Q13867 Q8R016 RefSeq (mRNA) NM_000386 NM_178645 RefSeq (protein) NP_000377 NP_848760 Location (UCSC) Chr 17: 30.25 – 30.29 Mb Chr 11: 76.82 – 76.88 Mb PubMed search [3] [4]
Wikidata
View/Edit Human View/Edit Mouse

Bleomycin hydrolase (BMH) is a cytoplasmic cysteine peptidase that is highly conserved through evolution. Its biological function is hydrolysis of the reactive electrophile homocysteine thiolactone.^[8] Another of its activities is metabolic inactivation of the glycopeptide bleomycin (BLM), an essential component of combination chemotherapy regimens for cancer. The protein contains the signature active site residues of the cysteine protease papain superfamily.^[7]

Interactions

BLMH has been shown to interact with RPL29,^[9] RPL11,^[9] UBE2I^[10] and Amyloid precursor protein.^[11]