Biliverdin reductase A

Biliverdin reductase A is a protein that in humans is encoded by the BLVRA gene.^[5][6]

biliverdin reductase A
Biliverdin reductase A dimer, Human
Identifiers
EC no.	1.3.1.24
Databases
IntEnz	IntEnz view
BRENDA	BRENDA entry
ExPASy	NiceZyme view
KEGG	KEGG entry
MetaCyc	metabolic pathway
PRIAM	profile
PDB structures	RCSB PDB PDBe PDBsum
Search PMC articles PubMed articles NCBI proteins

BLVRA
Available structures PDB Ortholog search: PDBe RCSB List of PDB id codes 2H63
Identifiers
Aliases	BLVRA, BLVR, BVR, BVRA, biliverdin reductase A
External IDs	OMIM: 109750; MGI: 88170; HomoloGene: 572; GeneCards: BLVRA; OMA:BLVRA - orthologs
Gene location (Human) Chr. Chromosome 7 (human)[1] Band 7p13 Start 43,758,680 bp[1] End 43,807,342 bp[1]
Gene location (Mouse) Chr. Chromosome 2 (mouse)[2] Band 2 F1|2 61.76 cM Start 126,912,585 bp[2] End 126,939,004 bp[2]
RNA expression pattern Bgee Human Mouse (ortholog) Top expressed in monocyte epithelium of esophagus middle temporal gyrus gingival epithelium corpus epididymis glomerulus spleen metanephric glomerulus olfactory zone of nasal mucosa right lung Top expressed in right kidney proximal tubule facial motor nucleus stroma of bone marrow human kidney endothelial cell of lymphatic vessel transitional epithelium of urinary bladder carotid body calvaria vestibular sensory epithelium More reference expression data BioGPS n/a
Gene ontology Molecular function protein binding metal ion binding zinc ion binding oxidoreductase activity biliverdin reductase (NAD(P)+) activity Cellular component extracellular exosome cytoplasm cytosol Biological process heme catabolic process Sources:Amigo / QuickGO
Orthologs Species Human Mouse Entrez 644 109778 Ensembl ENSG00000106605 ENSMUSG00000001999 UniProt P53004 Q9CY64 RefSeq (mRNA) NM_000712 NM_001253823 NM_026678 RefSeq (protein) NP_000703 NP_001240752 NP_080954 Location (UCSC) Chr 7: 43.76 – 43.81 Mb Chr 2: 126.91 – 126.94 Mb PubMed search [3] [4]
Wikidata
View/Edit Human View/Edit Mouse

Function

The protein encoded by this gene belongs to the biliverdin reductase family, members of which catalyze the conversion of biliverdin to bilirubin in the presence of NADPH or NADH.^[5]

Clinical significance

Mutations in this gene are associated with hyperbiliverdinemia.^[5]