Zinc finger protein basonuclin-2

Zinc finger protein basonuclin-2 is a protein that in humans is encoded by the BNC2 gene.^[5][6] BNC2 has recently been shown to influence skin pigmentation levels in Europeans.^[7] Genomic region spanning the BNC2 gene has 60% Neanderthal DNA sequence.^[8]

BNC2
Identifiers
Aliases	BNC2, BSN2, basonuclin 2, LUTO
External IDs	OMIM: 608669; MGI: 2443805; HomoloGene: 18243; GeneCards: BNC2; OMA:BNC2 - orthologs
Gene location (Human) Chr. Chromosome 9 (human)[1] Band 9p22.3-p22.2 Start 16,409,503 bp[1] End 16,870,843 bp[1]
Gene location (Mouse) Chr. Chromosome 4 (mouse)[2] Band 4|4 C3- C4 Start 84,193,332 bp[2] End 84,593,512 bp[2]
RNA expression pattern Bgee Human Mouse (ortholog) Top expressed in germinal epithelium sural nerve parietal pleura epithelium of colon hair follicle buccal mucosa cell left ovary right ovary myometrium testicle Top expressed in zygote oocyte secondary oocyte primary oocyte Gonadal ridge vas deferens sciatic nerve lumbar spinal ganglion hand trigeminal ganglion More reference expression data BioGPS More reference expression data
Gene ontology Molecular function metal ion binding DNA binding nucleic acid binding DNA-binding transcription factor activity, RNA polymerase II-specific Cellular component nucleus nucleoplasm plasma membrane cytosol Biological process tongue development endochondral bone growth regulation of transcription, DNA-templated mesenchyme development roof of mouth development transcription, DNA-templated regulation of transcription by RNA polymerase II Sources:Amigo / QuickGO
Orthologs Species Human Mouse Entrez 54796 242509 Ensembl ENSG00000173068 ENSMUSG00000028487 UniProt Q6ZN30 Q06HC2 Q8BMQ3 RefSeq (mRNA) NM_017637 NM_001317939 NM_001317940 NM_172870 NM_001369081 NM_001369082 NM_001369083 NM_001369084 RefSeq (protein) NP_001304868 NP_001304869 NP_060107 NP_766458 NP_001356010 NP_001356011 NP_001356012 NP_001356013 Location (UCSC) Chr 9: 16.41 – 16.87 Mb Chr 4: 84.19 – 84.59 Mb PubMed search [3] [4]
Wikidata
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See also

• Chromosome 9 (human)
• Zinc finger protein