BNR/Asp-box repeat

BNR/Asp-box repeat is a repetitive sequence of amino acids contained in some proteins. Many of these proteins contain multiple BNR (bacterial neuraminidase repeat) repeats or Asp-boxes.

BNR/Asp-box repeat
Structure of a bacterial sialidase.[1]
Identifiers
Symbol	BNR
Pfam	PF02012
Pfam clan	CL0434
InterPro	IPR002860
SCOP2	1euu / SCOPe / SUPFAM
Available protein structures: Pfam   structures / ECOD   PDB RCSB PDB; PDBe; PDBj PDBsum structure summary

The repeats are short, however the repeats are never found closer than 40 residues together suggesting that the repeat is structurally longer. The Asp-box itself adopts a well-defined beta-hairpin fold.^[2][3] These repeats are found in a variety of non-homologous proteins, including bacterial ribonucleases, sulphite oxidases, reelin, netrins, sialidases, neuraminidases, some lipoprotein receptors, and a variety of glycosyl hydrolases.^[4]

Examples

Human genes encoding proteins containing this domain include:

• NEU1
• NEU2
• NEU3
• RELN
• SORCS1
• SORCS2
• SORCS3
• SORL1
• SORT1