Sialidase-3

Sialidase-3 is an enzyme that in humans is encoded by the NEU3 gene.^[5][6]

NEU3
Identifiers
Aliases	NEU3, SIAL3, neuraminidase 3 (membrane sialidase), neuraminidase 3, membrane sialidase, neuraminidase 3
External IDs	OMIM: 604617; MGI: 1355305; HomoloGene: 4847; GeneCards: NEU3; OMA:NEU3 - orthologs
Gene location (Human) Chr. Chromosome 11 (human)[1] Band 11q13.4 Start 74,988,134 bp[1] End 75,018,893 bp[1]
Gene location (Mouse) Chr. Chromosome 7 (mouse)[2] Band 7|7 E1 Start 99,460,646 bp[2] End 99,477,624 bp[2]
RNA expression pattern Bgee Human Mouse (ortholog) Top expressed in Skeletal muscle tissue of rectus abdominis gastrocnemius muscle muscle of thigh right adrenal gland left adrenal cortex right adrenal cortex sural nerve biceps brachii Skeletal muscle tissue of biceps brachii right testis Top expressed in cumulus cell epithelium of small intestine thymus embryo muscle of thigh left lung lobe transitional epithelium of urinary bladder ectoderm otic vesicle saccule More reference expression data BioGPS More reference expression data
Gene ontology Molecular function alpha-sialidase activity exo-alpha-(2->6)-sialidase activity exo-alpha-(2->8)-sialidase activity hydrolase activity, acting on glycosyl bonds exo-alpha-(2->3)-sialidase activity hydrolase activity exo-alpha-sialidase activity Cellular component cytoplasm intracellular membrane-bounded organelle membrane plasma membrane integral component of plasma membrane Biological process glycosphingolipid metabolic process lipid metabolism lipid catabolic process oligosaccharide catabolic process metabolism ganglioside catabolic process carbohydrate metabolic process Sources:Amigo / QuickGO
Orthologs Species Human Mouse Entrez 10825 50877 Ensembl ENSG00000162139 ENSMUSG00000035239 UniProt Q9UQ49 Q9JMH7 RefSeq (mRNA) NM_006656 NM_016720 RefSeq (protein) NP_006647 NP_001354789 NP_001354790 NP_001354791 NP_001354792 NP_001354793 NP_001354794 NP_001354795 NP_001354796 NP_057929 Location (UCSC) Chr 11: 74.99 – 75.02 Mb Chr 7: 99.46 – 99.48 Mb PubMed search [3] [4]
Wikidata
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Function

This gene product belongs to a family of glycohydrolytic enzymes which remove sialic acid residues from glycoproteins and glycolipids. It is localized in the plasma membrane, and its activity is specific for gangliosides. It may play a role in modulating the ganglioside content of the lipid bilayer.^[6]

Interactions

Sialidase-3 has been shown to interact with Grb2.^[7]