BPC-157

Gastric Pentadecapeptide BPC-157 (also known as PL 14736, Body Protection Compound 157, or Bepecin) is a fifteen amino acid long oligopeptide that was discovered during research on human gastric juice.^[1] The amino acid sequence is as follows: Gly-Glu-Pro-Pro-Pro-Gly-Lys-Pro-Ala-Asp-Asp-Ala-Gly-Leu-Val.^[2]

BPC-157

Identifiers
CAS Number	137525-51-0 N
3D model (JSmol)	Interactive image
ChEMBL	ChEMBL4297358 Y
ChemSpider	8117571
DrugBank	DB11882
PubChem CID	9941957
UNII	8ED8NXK95P Y
InChI InChI=1S/C62H98N16O22/c1-31(2)25-37(55(92)74-50(32(3)4)62(99)100)71-46(81)29-65-51(88)33(5)67-53(90)38(26-48(84)85)73-54(91)39(27-49(86)87)72-52(89)34(6)68-57(94)41-15-10-21-75(41)58(95)35(13-7-8-20-63)70-45(80)30-66-56(93)40-14-9-22-76(40)60(97)43-17-12-24-78(43)61(98)42-16-11-23-77(42)59(96)36(18-19-47(82)83)69-44(79)28-64/h31-43,50H,7-30,63-64H2,1-6H3,(H,65,88)(H,66,93)(H,67,90)(H,68,94)(H,69,79)(H,70,80)(H,71,81)(H,72,89)(H,73,91)(H,74,92)(H,82,83)(H,84,85)(H,86,87)(H,99,100)/t33-,34-,35-,36-,37-,38-,39-,40-,41-,42-,43-,50-/m0/s1 Key: HEEWEZGQMLZMFE-RKGINYAYSA-N
SMILES C[C@@H](C(=O)N[C@@H](CC(=O)O)C(=O)N[C@@H](CC(=O)O)C(=O)N[C@@H](C)C(=O)NCC(=O)N[C@@H](CC(C)C)C(=O)N[C@@H](C(C)C)C(=O)O)NC(=O)[C@@H]1CCCN1C(=O)[C@H](CCCCN)NC(=O)CNC(=O)[C@@H]2CCCN2C(=O)[C@@H]3CCCN3C(=O)[C@@H]4CCCN4C(=O)[C@H](CCC(=O)O)NC(=O)CN
Properties
Chemical formula	C62H98N16O22
Molar mass	1419.5 g/mol
Except where otherwise noted, data are given for materials in their standard state (at 25 °C [77 °F], 100 kPa). N (what is YN ?) Infobox references

BPC-157 is stable at room temperature and bioavailable in rodent models when administered IM or IV.^[3]

Research

Pre-clinical research has indicated that BPC-157 may have cytoprotective, neuroprotective, and anti-inflammatory effects, and may also accelerate tissue and organ healing.^{[4][5][6][7] [8][9]}

This substance is sometimes used in functional medicine despite not being approved by any drug regulatory agency.^[10]

As of 2022, the peptide is banned by the World Anti-Doping Agency under the S0 category of non-exempt substances.^[11]

Detection

BPC-157 is detected in urine using a weak cation exchange solid phase extraction and was found to be stable in urine for 4 days.^[12]