BRL-15572

BRL-15,572 is a drug which acts as a selective antagonist for the serotonin receptor subtype 5-HT_1D, with around 60x selectivity over other related receptors. The 5-HT_1D receptor has a very similar pharmacology to the closely related 5-HT_1B receptor, and most older ligands for these receptors bind to both subtypes with approximately equal affinity, so development of compounds such as BRL-15572 which are able to selectively block the 5-HT_1D subtype while leaving 5-HT_1B unaffected, have been a significant advance which has helped scientists in researching the function of these serotonin receptor subtypes.^[1][2] One function of the 5-HT_1D receptor this research has revealed is its role in modulating release of the neurotransmitter glutamate in the brain,^[3] as well as functions in regulation of cerebral blood pressure which are important in the pathogenesis of migraine headaches.^[4]

BRL-15572

Clinical data
ATC code	none
Identifiers
IUPAC name 3-(4-(3-chlorophenyl)piperazin-1-yl)-1,1-diphenyl-2-propanol
CAS Number	193611-72-2 Y
PubChem CID	3654103
IUPHAR/BPS	10
ChemSpider	2887678 N
UNII	X83G4TN8JZ
ChEMBL	ChEMBL534232 N
CompTox Dashboard (EPA)	DTXSID4043983
Chemical and physical data
Formula	C25H27ClN2O
Molar mass	406.95 g·mol−1
3D model (JSmol)	Interactive image
SMILES Clc2cccc(c2)N1CCN(CC1)CC(O)C(c3ccccc3)c4ccccc4
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