BW373U86

(+)-BW373U86 is an opioid analgesic drug used in scientific research.^[1][2]

BW373U86

Clinical data
Other names	(+)-BW373U86
Identifiers
IUPAC name 4-[(R)-[(2S,5R)-2,5-dimethyl-4-prop-2-enylpiperazin-1-yl]-(3-hydroxyphenyl)methyl]-N,N-diethylbenzamide
CAS Number	150428-54-9 Y
PubChem CID	119029
ChemSpider	106357 N
UNII	RR2QFN29K7
ChEMBL	ChEMBL25230 N
CompTox Dashboard (EPA)	DTXSID00933945
Chemical and physical data
Formula	C27H37N3O2
Molar mass	435.612 g·mol−1
3D model (JSmol)	Interactive image
SMILES CCN(CC)C(=O)C1=CC=C(C=C1)C(C2=CC(=CC=C2)O)N3CC(N(CC3C)CC=C)C
InChI InChI=1S/C27H37N3O2/c1-6-16-29-18-21(5)30(19-20(29)4)26(24-10-9-11-25(31)17-24)22-12-14-23(15-13-22)27(32)28(7-2)8-3/h6,9-15,17,20-21,26,31H,1,7-8,16,18-19H2,2-5H3/t20-,21+,26-/m1/s1 N Key:LBLDMHBSVIVJPM-YZIHRLCOSA-N N
NY (what is this?)  (verify)

BW373U86 is a selective agonist for the δ-opioid receptor, with approximately 15× stronger affinity for the δ-opioid than the μ-opioid receptor.^[3] It has potent analgesic and antidepressant effects in animal studies.^[4][5] In studies on rats, BW373U86 appears to protect heart muscle cells from apoptosis in conditions of ischemia (oxygen deprivation, such as in heart attack). The mechanism for this is complex and may be separate from its delta agonist effects.^[6][7][8]

CNS review:^[9]

See also

• AZD2327
• DPI-287
• DPI-3290