Bag-1 internal ribosome entry site (IRES)

The BAG-1 internal ribosome entry site (IRES) is a cis-acting element located in the 5 ' untranslated region of the BAG-1 protein mRNA. It affects apoptosis through IRES-mediated translation of the BAG-1 protein.^[1]

Bag-1 internal ribosome entry site (IRES)
Predicted secondary structure and sequence conservation of IRES_Bag1
Identifiers
Symbol	IRES_Bag1
Alt. Symbols	Bag1_IRES
Rfam	RF00222
Other data
RNA type	Cis-reg; IRES
Domain(s)	Eukaryota
GO	GO:0043022
SO	SO:0000243
PDB structures	PDBe

When expressed, the BAG-1 protein is known to enhance the anti-apoptotic properties of the Bcl-2 protein. Although BAG-1 translation usually occurs via a cap-dependent mechanism, it has been found to contain an IRES in its 5' UTR. Translation via the IRES has been found to be common following heat shock when cap-dependent scanning is compromised.^[1]