Balding–Nichols model

Model in population genetics From Wikipedia, the free encyclopedia

Balding–Nichols model

In population genetics, the Balding–Nichols model is a statistical description of the allele frequencies in the components of a sub-divided population.[1] With background allele frequency p the allele frequencies, in sub-populations separated by Wright's FST F, are distributed according to independent draws from

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Balding-Nichols
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where B is the Beta distribution. This distribution has mean p and variance Fp(1  p).[2]

The model is due to David Balding and Richard Nichols and is widely used in the forensic analysis of DNA profiles and in population models for genetic epidemiology.


References

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