Basopenia

Basopenia (or basocytopenia) is a form of agranulocytosis associated with a deficiency of basophils.^[1] It has been proposed as an indicator of ovulation.^[2] It is difficult to detect without flow cytometry, because normal levels are so low.^[3] It can be defined as less than 0.01 x 10⁹ / L.^[4] Basopenia has been observed in a number of conditions, including after the administration of corticosteroids and in disease states such as chronic urticaria and lupus.^[5]

Basopenia
A peripheral blood basophil stained with a Romanovsky stain.
Specialty	Hematology

Mechanism

Main article: Basophils

Basophils, which account for a small proportion of the total leukocyte count, are phagocytic. Heparin, histamine, and serotonin are found in the basophilic granules. Mast cells are tissue basophils that are similar to blood basophils. Mast cells are normally not found in peripheral blood and are only rarely found in healthy bone marrow. Chronic inflammation is assessed using basophil counts. Although there is a positive correlation between higher basophil counts and high blood histamine concentrations, this correlation is not indicative of cause and effect.^[6]

Associated conditions

• Hereditary absence of basophils (very rare)
• Elevated levels of glucocorticoids
• Hyperthyroidism or treatment with thyroid hormones
• Ovulation
• Hypersensitivity reactions

• urticaria^[7][8][9]
• Anaphylaxis
• Drug-induced reactions

• Leukocytosis (in association with diverse disorders)