Benzthiazide

Benzthiazide (BAN/INN, also known as benzothiazide; trade names Aquatag, Dihydrex, Diucen, Edemax, Exna, Foven and others^[1]) is a thiazide diuretic used in the treatment of high blood pressure and edema. It is no longer available in the United States.

Benzthiazide

Clinical data
AHFS/Drugs.com	International Drug Names
Routes of administration	Oral
ATC code	none
Legal status
Legal status	In general: ℞ (Prescription only)
Pharmacokinetic data
Bioavailability	60 to 70%
Protein binding	30%
Elimination half-life	5 to 15 hours
Excretion	Renal
Identifiers
IUPAC name 6-chloro-1,1-dioxo-3-(phenylmethylsulfanylmethyl)- 4H-benzo[e][1,2,4]thiadiazine-7-sulfonamide
CAS Number	91-33-8 Y
PubChem CID	2343
IUPHAR/BPS	7125
DrugBank	DB00562 Y
ChemSpider	2253 Y
UNII	1TD8J48L61
KEGG	D00651 Y
ChEBI	CHEBI:3047 Y
ChEMBL	ChEMBL1201039 N
CompTox Dashboard (EPA)	DTXSID4022658
ECHA InfoCard	100.001.874
Chemical and physical data
Formula	C15H14ClN3O4S3
Molar mass	431.92 g·mol−1
3D model (JSmol)	Interactive image
SMILES O=S(=O)(c1c(Cl)cc2c(c1)S(=O)(=O)/N=C(\N2)CSCc3ccccc3)N
InChI InChI=1S/C15H14ClN3O4S3/c16-11-6-12-14(7-13(11)25(17,20)21)26(22,23)19-15(18-12)9-24-8-10-4-2-1-3-5-10/h1-7H,8-9H2,(H,18,19)(H2,17,20,21) Y Key:NDTSRXAMMQDVSW-UHFFFAOYSA-N Y
NY (what is this?)  (verify)

In the United Kingdom, it was also sold in combination with the potassium-sparing diuretic triamterene under the trade name Dytide.^[2] The same combination is still available in Switzerland as Dyrenium compositum.^[3]