Biphasic disease

A biphasic disease is a disease which has two distinct phases or components. In clinically biphasic diseases, the phases are generally chronologically separated. In histopathologically biphasic tumors (also called biplastic tumors), there is neoplastic tissue which contains two different cellular elements.^[1][2]

Examples

Clinically biphasic diseases

Disease	Typical first phase	Typical second phase
European (or "Western") subtype of tick-borne encephalitis virus[3][4]	Relatively mild flu-like illness	Affecting some cases, generally presenting with high fever and neurologic disease (encephalitis), meningitis and/or meningoencephalitis)
Leptospirosis[5]	4–9 days of abrupt onset of flu-like illness	Fever, jaundice, abdominal pain and diarrhoea. Organ failure in severe cases.
Anthrax[6]	After approximately 4 days, patients develop flu-like illness with fever, nonproductive cough, and myalgias lasting approximately 4 days	Without timely treatment, a second fulminant phase follows, characterized by hypotension and dyspnea. This phase may progress to death within 24 hours of its onset.[6]

Tumor biplasia

Main article: Mixed tumor

Disease	Cellular elements
Fibroadenoma[1][7]	Epithelium	Stroma
Ceruminous adenoma[8]	Inner luminal secretory cells	Myoepithelial cells