Bisphenol

Not to be confused with biphenol.

The bisphenols (/ˈbɪsfɪnɒl/) are a group of industrial chemical compounds related to diphenylmethane; commonly used in the production of plastics and epoxy resins. They feature two hydroxyphenyl groups linked by a methylene bridge. Also included are bisphenol S, P, and M. "Bisphenol" is a common name; the letter following denotes the variant, which depends on the additional substituents. Bisphenol A is the most common representative of the group, with millions of metric tons produced globally in the past decade, often simply called "bisphenol".^[1]

Bisphenols have attracted controversy because of their role as endocrine disruptors.^[2][3]

List

Structural formula	Name	CAS	Reactants
	Bisphenol A	80-05-7	Phenol	Acetone
	Bisphenol AP	1571-75-1	Phenol	Acetophenone
	Bisphenol AF	1478-61-1	Phenol	Hexafluoroacetone
	Bisphenol B	77-40-7	Phenol	Butanone
	Bisphenol BP	1844-01-5	Phenol	Benzophenone
	Bisphenol C	79-97-0	o-cresol	Acetone
	Bisphenol C 2	14868-03-2	Phenol	Chloral
	Bisphenol E	2081-08-5	Phenol	Ethanal
	Bisphenol F	620-92-8	Phenol	Formaldehyde
	Bisphenol G	127-54-8	2-Isopropylphenol	Acetone
	Bisphenol M	13595-25-0
	Bisphenol S	80-09-1	Phenol	Sulfur trioxide
	Bisphenol P	2167-51-3
	Bisphenol PH	24038-68-4	2-Phenylphenol	Acetone
	Bisphenol TMC	129188-99-4	Phenol	3,3,5-Trimethylcyclohexanone
	Bisphenol Z	843-55-0	Phenol	Cyclohexanone
	Dinitrobisphenol A	5329-21-5	Bisphenol A	Nitric acid
	Tetrabromobisphenol A	79-94-7	Bisphenol A	Bromine
	Tetramethyl bisphenol F	5384-21-4	2,6-Xylenol	Formaldehyde

Health effects

Bisphenols A (BPA), F (BPF) and S (BPS) have been shown to be endocrine disruptors, potentially relating to adverse health effects.^[2][4] Due to its high production volumes, BPA has been characterised as a "pseudo-persistent" chemical,^[5] leading to its spreading and potential accumulation in a variety of environmental matrices, even though it has a fairly short half-life.^[6][7][8][2]