Bone morphogenetic protein receptor

Bone morphogenetic protein receptors are serine-threonine kinase receptors. Transforming growth factor beta family proteins bind to these receptors.^[1] There are four bone morphogenetic protein receptors:^[2]

• Bone morphogenetic protein receptor, type 1:
  • ACVR1
  • BMPR1A
  • BMPR1B
• Bone morphogenetic protein receptor, type 2

TKL Ser/Thr protein kinase family
Identifiers
Symbol	TKL
Membranome	1216

Structure

Both type 1 and 2 bone morphogenetic protein receptors have a single transmembrane segment. Additionally, both types have a cysteine-rich extracellular domain and a cytoplasmic serine threonine kinase domain.^[3] Type 1 contains a glycine-serine-rich domain to be phosphorylated by type 2 kinase domain, initiating the signaling transduction pathway of the SMAD signaling cascade.^[3] The wrist epitope motif on BMP-2 has a high-affinity binding site for BMPR-IA. The knuckle epitope motif on BMP-2 has a low-affinity binding site for BMPR-II.^[4]

See also

• Bone morphogenetic protein