CDCA8

Borealin is a protein that in humans is encoded by the CDCA8 gene.^[5][6][7]

CDCA8
Available structures PDB Ortholog search: PDBe RCSB List of PDB id codes 2KDD, 2QFA, 2RAW, 2RAX
Identifiers
Aliases	CDCA8, BOR, BOREALIN, DasraB, MESRGP, cell division cycle associated 8
External IDs	OMIM: 609977; MGI: 1196274; HomoloGene: 23075; GeneCards: CDCA8; OMA:CDCA8 - orthologs
Gene location (Human) Chr. Chromosome 1 (human)[1] Band 1p34.3 Start 37,692,481 bp[1] End 37,709,719 bp[1]
Gene location (Mouse) Chr. Chromosome 4 (mouse)[2] Band 4 D2.2|4 57.93 cM Start 124,812,258 bp[2] End 124,833,104 bp[2]
RNA expression pattern Bgee Human Mouse (ortholog) Top expressed in oocyte secondary oocyte ventricular zone gonad embryo ganglionic eminence right testis left testis mucosa of transverse colon testicle Top expressed in Paneth cell renal corpuscle condyle primitive streak fossa primary oocyte ureter medullary collecting duct zygote endocardial cushion More reference expression data BioGPS More reference expression data
Gene ontology Molecular function protein binding Cellular component intercellular bridge nucleolus nucleoplasm cytoplasm spindle chromosome cytosol nucleus chromosome, centromeric region chromocenter midbody chromosome passenger complex spindle midzone cytoskeleton protein-containing complex Biological process chromosome organization cell cycle cell division mitotic metaphase plate congression mitotic sister chromatid segregation Sources:Amigo / QuickGO
Orthologs Species Human Mouse Entrez 55143 52276 Ensembl ENSG00000134690 ENSMUSG00000028873 UniProt Q53HL2 Q8BHX3 RefSeq (mRNA) NM_018101 NM_001256875 NM_026560 RefSeq (protein) NP_001243804 NP_060571 NP_080836 Location (UCSC) Chr 1: 37.69 – 37.71 Mb Chr 4: 124.81 – 124.83 Mb PubMed search [3] [4]
Wikidata
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Function

CDCA8 is a component of a chromosomal passenger complex required for stability of the bipolar mitotic spindle.^[7][8]

Interactions

CDCA8 has been shown to interact with INCENP,^[8] Survivin^[6][8] and Aurora B kinase.^[6][8]