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Brian Druker

American physician-scientist From Wikipedia, the free encyclopedia

Brian Druker
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Brian J. Druker, M.D. (born April 30, 1955)[1] is a physician-scientist and JELD-WEN Chair of Leukemia Research at Oregon Health & Science University (OHSU) in Portland, Oregon. He previously served as chief executive officer and director of OHSU's Knight Cancer Institute,[2][3][4] as well as Associate Dean for Oncology in the OHSU School of Medicine.[5]

Quick facts Born, Alma mater ...

Druker helped develop imatinib (Gleevec), the first medication that specifically targets cancer cells, for the treatment of chronic myeloid leukemia (CML).[6][7][8] In 2001, Gleevec gained FDA approval in record time[9] and landed on the cover of Time magazine.[10] Druker’s work launched the era of precision cancer medicine, setting the stage for future discoveries in the quest to end cancer.[11]

He is the recipient of the 2009 Lasker-DeBakey Clinical Medical Research Award,[12] the 2012 Japan Prize in Healthcare and Medical Technology,[13] the 2013 Albany Medical Center Prize in Medicine and Biomedical Research,[14] and the 2019 Sjöberg Prize,[15] among others. He has been called "Oregon's best-known scientist".[16]

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Education

Druker earned both his B.A. degree in chemistry and M.D. degree from the University of California, San Diego.[17] He completed his internship and residency in internal medicine at Barnes Hospital, Washington University School of Medicine in St. Louis from 1981 to 1984.[18]

Research and Leadership

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Druker was a fellow in medical oncology at Dana–Farber Cancer Institute at Harvard Medical School from 1984 to 1987. He began working at Oregon Health & Science University (OHSU) in 1993.[19]

Druker's research is focused on translating the knowledge of the molecular pathogenesis of cancer into specific therapies and investigating the optimal use of these molecularly targeted agents. He performed preclinical studies that led to the development of imatinib (Gleevec) for chronic myeloid leukemia (CML) and then spearheaded the highly successful clinical trials of imatinib, which led to FDA approval of the drug in record time.[6][8][7] This work changed the life expectancy of patients with CML from an average of 3 to 5 years to a 89% five-year survival,[20][21] and has resulted in a paradigm-shift in cancer treatment from non-specific chemotherapy to highly targeted therapeutic agents.[22] Druker has been widely recognized for his work in developing Gleevec, but has been publicly critical of the drug's high price for patients.[23][24]

Druker also helped lead a national clinical trial to find effective treatments for acute myeloid leukemia (AML). The Beat AML clinical trial, sponsored by the Leukemia & Lymphoma Society (LLS), is a joint effort by medical centers, drug makers and the Food and Drug Administration.[25]

In May 2007, he became director of the OHSU Cancer Institute—renamed the Knight Cancer Institute in October 2008 following a $100 million donation from Nike co-founder Phil Knight.[26]

In 2015, Druker celebrated the completion of the Knight Cancer Challenge, raising $1 billion for research at the Knight Cancer Institute.[27] The Oregon Legislature and more than 10,000 donors from Oregon and beyond matched a $500 million grant from Phil and Penny Knight.[3] The challenge gave the institute the funding to launch the Cancer Early Detection Advanced Research Center.[3]

In March 2024, he transitioned to the role of chief executive officer of the Knight Cancer Institute.[28] Druker abruptly resigned in December 2024 while "looking for opportunities where (he) can continue to make an impact on patient’s lives and on the world."[29] He continues to lead his research lab and see patients, but has expressed strong criticism of OHSU, stating that the institution has "lost sight of what is crucial and forgotten (its) mission."[30][31]

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Memberships and Awards

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Druker was an investigator of Howard Hughes Medical Institute (HHMI) from 2002 to 2019.[19] He was elected to the National Academy of Medicine (formerly Institute of Medicine) in 2003 and the National Academy of Sciences in 2007. He is a member of the American Society for Clinical Investigation, Association of American Physicians, American Academy of Arts and Sciences, American Association for the Advancement of Science, American Society of Hematology, American Society for Microbiology, American Society of Clinical Oncology, American Association for Cancer Research, Children’s Oncology Group, and The American Society for Cell Biology. Druker has received the following awards, among others:[32]

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Personal

Druker is married to Alexandra Hardy, a one-time reporter for People magazine, and the couple have three children (as of 2009).[9] An earlier marriage, to Barbara Rodriguez in 1990, ended in divorce in 1999.[17]

References

External links

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