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Buehler test
Medical procedure From Wikipedia, the free encyclopedia
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The Buehler test is an in vivo test to screen for substances that cause human skin sensitisation (i.e. allergens). It was first proposed by Edwin Vernon Buehler in 1965[1] and further explained in 1980.[2]
It is a non-adjuvant test. In the test, guinea pigs are exposed to a high dose of the substance. They are then given a challenge dose, which is the highest dose that does not cause irritation.[3]
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