Rs1800955

In genetics, rs1800955 (also written as C-521T and -521C/T) is a single nucleotide polymorphism (SNP). It is located in the promoter region of the DRD4 gene. This gene codes for the dopamine receptor D4.

SNP: rs1800955
Name(s)	C-521T, -521C/T
Gene	DRD4
Chromosome	11
Region	Promoter
External databases
Ensembl	Human SNPView
dbSNP	1800955
HapMap	1800955
SNPedia	1800955
ALFRED	SI000215I
SzGene	Meta-analysis Overview

Due to the dopamine hypothesis of schizophrenia the SNP has been investigated for link to schizophrenia, and it may be slightly associated with this disorder.^[1]

The SNP has been investigated with respect to novelty seeking, — a personality trait that may be measured with the Temperament and Character Inventory.^[2][3] A 2008 meta-analysis indicates a possible association between novelty seeking and C-521T though rather small.^[4]