Natriuretic peptide precursor C

Natriuretic peptide precursor C, also known as NPPC, is a protein that in humans is encoded by the NPPC gene.^[5][6][7] The precursor NPPC protein is cleaved to the 22 amino acid peptide C-type natriuretic peptide (CNP).

NPPC
Available structures PDB Ortholog search: PDBe RCSB List of PDB id codes 1JDP
Identifiers
Aliases	NPPC, CNP, CNP2, Natriuretic peptide precursor C, natriuretic peptide C
External IDs	OMIM: 600296; MGI: 97369; HomoloGene: 7867; GeneCards: NPPC; OMA:NPPC - orthologs
Gene location (Human) Chr. Chromosome 2 (human)[1] Band 2q37.1 Start 231,921,809 bp[1] End 231,926,396 bp[1]
Gene location (Mouse) Chr. Chromosome 1 (mouse)[2] Band 1 C5|1 43.98 cM Start 86,594,013 bp[2] End 86,598,293 bp[2]
RNA expression pattern Bgee Human Mouse (ortholog) Top expressed in testicle C1 segment prefrontal cortex Brodmann area 9 apex of heart anterior cingulate cortex right hemisphere of cerebellum olfactory zone of nasal mucosa left ventricle Hypothalamus Top expressed in lumbar subsegment of spinal cord embryo embryo morula lip superior frontal gyrus primary visual cortex dentate gyrus of hippocampal formation granule cell cumulus cell cerebellar cortex More reference expression data BioGPS More reference expression data
Gene ontology Molecular function protein homodimerization activity hormone activity peptide hormone receptor binding signaling receptor binding hormone receptor binding Cellular component secretory granule extracellular region extracellular space protein-containing complex Biological process animal organ development negative regulation of meiotic cell cycle regulation of cardiac conduction growth plate cartilage chondrocyte proliferation response to hypoxia ossification regulation of multicellular organism growth negative regulation of oocyte maturation growth plate cartilage chondrocyte differentiation post-embryonic development receptor guanylyl cyclase signaling pathway regulation of smooth muscle cell proliferation cGMP biosynthetic process positive regulation of osteoblast differentiation negative regulation of DNA metabolic process response to ethanol negative regulation of cell population proliferation protein folding regulation of signaling receptor activity reproductive process cGMP-mediated signaling positive regulation of cGMP-mediated signaling negative regulation of collagen biosynthetic process negative regulation of DNA biosynthetic process Sources:Amigo / QuickGO
Orthologs Species Human Mouse Entrez 4880 18159 Ensembl ENSG00000163273 ENSMUSG00000026241 UniProt P23582 Q61839 RefSeq (mRNA) NM_024409 NM_010933 RefSeq (protein) NP_077720 NP_035063 Location (UCSC) Chr 2: 231.92 – 231.93 Mb Chr 1: 86.59 – 86.6 Mb PubMed search [3] [4]
Wikidata
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Function

Structure of C-type natriuretic peptide (human)

Natriuretic peptides comprise a family of 3 structurally related molecules: atrial natriuretic peptide (ANP), brain natriuretic peptide (BNP), and C-type natriuretic peptide (CNP), encoded by a gene symbolized NPPC. These peptides possess potent natriuretic, diuretic, and vasodilating activities and are implicated in body fluid homeostasis and blood pressure control.^[5] Unlike ANP and BNP, CNP does not have direct natriuretic activity. This is because CNP is a selective agonist for the B-type natriuretic receptor (NPRB) whereas ANP and BNP are selective for the A-type natriuretic receptor (NPRA).^[8] It is synthesized and secreted from the endothelium in response to many stimuli, for example shear stress (like NO^{[clarification needed]}) and certain proinflammatory cytokines.^[9]