Rs1805054

In genetics, Rs1805054, also called C267T, is a name used for a specific genetic variation, a single nucleotide polymorphism (SNP), in the HTR6 gene. It is one of the few investigated polymorphisms of its gene. C267T is a synonymous polymorphism.

SNP: rs1805054
Name(s)	C267T, 267T/C
Gene	HTR6
Chromosome	1
External databases
Ensembl	Human SNPView
dbSNP	1805054
HapMap	1805054
SNPedia	1805054
AlzGene	Meta-analysis Overview

As of 2008 meta-analysis of the polymorphism and Alzheimer's disease indicates that there probably is no association between the two,^[1] though individual studies report such an association, e.g., a Chinese study found an association with late-onset Alzheimer's disease.^[2] Another reported association in neuropsychiatry disorders is with treatment response in depression.^[3]

C267T has also been examined in relation to personality traits, with a Korean study finding some evidence for an association with the trait self-transcendence.^[4] A Japanese study reported no association with personality traits using the NEO PI-R personality inventory.^[5]