AMG-36

AMG-36 (part of the AM cannabinoid series) is an analgesic drug which is a cannabinoid agonist. It is a derivative of Δ⁸-THC substituted with a cyclopentane group on the 3-position side chain. AMG-36 is a potent agonist at both CB₁ and CB₂ with moderate selectivity for CB₁, with a K_i of 0.45 nM at CB₁ vs 1.92 nM at CB₂.^[1][2]

AMG-36

Identifiers
IUPAC name (6aR,10aR)-3-(1-hexylcyclopentyl)-6,6,9-trimethyl-6a,7,10,10a-tetrahydrobenzo[c]chromen-1-ol
CAS Number	579444-43-2
PubChem CID	10982174
ChemSpider	9157375 Y
ChEMBL	ChEMBL108868 Y
CompTox Dashboard (EPA)	DTXSID001027467
Chemical and physical data
Formula	C27H40O2
Molar mass	396.615 g·mol−1
3D model (JSmol)	Interactive image
SMILES CC2(C)Oc1cc(C4(CCCCCC)CCCC4)cc(O)c1C(C3)C2CC=C3C
InChI InChI=1S/C27H40O2/c1-5-6-7-8-13-27(14-9-10-15-27)20-17-23(28)25-21-16-19(2)11-12-22(21)26(3,4)29-24(25)18-20/h11,17-18,21-22,28H,5-10,12-16H2,1-4H3/t21-,22-/m1/s1 Y Key:FONCHEGPDSYFCG-FGZHOGPDSA-N Y
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See also

• AMG-3
• AMG-41