C8 complex

Complement component 8 is a protein involved in the complement system. It is part of the membrane attack complex (MAC).

High Resolution Crystal Structure of Human Complement Component 8^[1]

A hereditary deficiency of C8 can result in increased susceptibility to Neisseria infections, such as meningitis and gonorrhea.

Membrane attack complex. Some labels are in Polish.

complement component 8, alpha polypeptide Identifiers Symbol C8A NCBI gene 731 HGNC 1352 OMIM 120950 RefSeq NM_000562 UniProt P07357 Other data Locus Chr. 1 p36.2-22.1 Search for Structures Swiss-model Domains InterPro

complement component 8, beta polypeptide Identifiers Symbol C8B NCBI gene 732 HGNC 1353 OMIM 1209660 RefSeq NM_000066 UniProt P073o58 Other data Locus Chr. 1 p36.2-22.1 Search for Structures Swiss-model Domains InterPro

complement component 8, gamma polypeptide Identifiers Symbol C8G NCBI gene 733 HGNC 1354 OMIM 120930 RefSeq NM_000606 UniProt P07360 Other data Locus Chr. 9 q34.3 Search for Structures Swiss-model Domains InterPro

Structure

C8 is a heterotrimer; it consists of three different subunits. These are called C8 alpha, beta and gamma chains, encoded by the genes C8A, C8B and C8G respectively.