Carbonic anhydrase 14

Carbonic anhydrase 14 is an enzyme that in humans is encoded by the CA14 gene.^[5][6]

CA14
Available structures PDB Ortholog search: PDBe RCSB List of PDB id codes 4LU3, 5CJF
Identifiers
Aliases	CA14, CAXiV, carbonic anhydrase 14
External IDs	OMIM: 604832; MGI: 1344341; HomoloGene: 69105; GeneCards: CA14; OMA:CA14 - orthologs
Gene location (Human) Chr. Chromosome 1 (human)[1] Band 1q21.2 Start 150,257,251 bp[1] End 150,265,078 bp[1]
Gene location (Mouse) Chr. Chromosome 3 (mouse)[2] Band 3|3 F2.1 Start 95,805,080 bp[2] End 95,812,003 bp[2]
RNA expression pattern Bgee Human Mouse (ortholog) Top expressed in retinal pigment epithelium C1 segment substantia nigra Epithelium of choroid plexus vastus lateralis muscle ventricular zone corpus callosum embryo apex of heart Skeletal muscle tissue of rectus abdominis Top expressed in retinal pigment epithelium choroid plexus of fourth ventricle Epithelium of choroid plexus right kidney epithelium of lens epiblast interventricular septum stria vascularis cardiac muscle tissue of left ventricle muscle of thigh More reference expression data BioGPS More reference expression data
Gene ontology Molecular function metal ion binding lyase activity carbonate dehydratase activity zinc ion binding carbonic anhydrase Cellular component plasma membrane membrane integral component of membrane Biological process bicarbonate transport Sources:Amigo / QuickGO
Orthologs Species Human Mouse Entrez 23632 23831 Ensembl ENSG00000118298 ENSMUSG00000038526 UniProt Q9ULX7 Q9WVT6 RefSeq (mRNA) NM_012113 NM_011797 NM_001355750 NM_001355751 NM_001355752 RefSeq (protein) NP_036245 NP_035927 NP_001342679 NP_001342680 NP_001342681 Location (UCSC) Chr 1: 150.26 – 150.27 Mb Chr 3: 95.81 – 95.81 Mb PubMed search [3] [4]
Wikidata
View/Edit Human View/Edit Mouse

Carbonic anhydrases (CAs) are a large family of zinc metalloenzymes that catalyze the reversible hydration of carbon dioxide. They participate in a variety of biological processes, including respiration, calcification, acid-base balance, bone resorption, and the formation of aqueous humor, cerebrospinal fluid, saliva, and gastric acid. They show extensive diversity in tissue distribution and in their subcellular localization. CA XIV is predicted to be a type I membrane protein and shares highest sequence similarity with the other transmembrane CA isoform, CA XII; however, they have different patterns of tissue-specific expression and thus may play different physiologic roles.^[6]

In melanocytic cells CA14 gene expression may be regulated by MITF.^[7]