Calcitonin receptor

The calcitonin receptor (CT) is a G protein-coupled receptor that binds the peptide hormone calcitonin and is involved in maintenance of calcium homeostasis,^[5] particularly with respect to bone formation and metabolism.^[6][7][8]

CALCR
Available structures PDB Ortholog search: PDBe RCSB List of PDB id codes 5II0
Identifiers
Aliases	CALCR, CRT, CT-R, CTR, CTR1, calcitonin receptor
External IDs	OMIM: 114131; MGI: 101950; HomoloGene: 1320; GeneCards: CALCR; OMA:CALCR - orthologs
Gene location (Human) Chr. Chromosome 7 (human)[1] Band 7q21.3 Start 93,424,486 bp[1] End 93,574,730 bp[1]
Gene location (Mouse) Chr. Chromosome 6 (mouse)[2] Band 6 A1|6 1.81 cM Start 3,685,680 bp[2] End 3,764,714 bp[2]
RNA expression pattern Bgee Human Mouse (ortholog) Top expressed in tibia hypothalamus muscle of thigh human kidney placenta metanephros skeletal muscle tissue renal cortex ligament tendon Top expressed in arcuate nucleus median eminence dorsomedial hypothalamic nucleus paraventricular nucleus of hypothalamus suprachiasmatic nucleus nucleus accumbens morula lateral hypothalamus ventromedial nucleus embryo More reference expression data BioGPS More reference expression data
Gene ontology Molecular function G protein-coupled receptor activity calcitonin receptor activity calcitonin binding signal transducer activity protein binding transmembrane signaling receptor activity amyloid-beta binding calcitonin gene-related peptide receptor activity amylin receptor activity Cellular component integral component of membrane membrane plasma membrane integral component of plasma membrane axon amylin receptor complex 1 amylin receptor complex 2 amylin receptor complex 3 Biological process positive regulation of adenylate cyclase activity adenylate cyclase-activating G protein-coupled receptor signaling pathway positive regulation of cytosolic calcium ion concentration receptor internalization response to glucocorticoid activation of phospholipase C activity activation of adenylate cyclase activity cell surface receptor signaling pathway protein transport protein localization to plasma membrane signal transduction G protein-coupled receptor signaling pathway positive regulation of gene expression positive regulation of protein kinase A signaling positive regulation of cell death positive regulation of peptidyl-serine phosphorylation cross-receptor inhibition within G protein-coupled receptor heterodimer positive regulation of protein kinase B signaling positive regulation of ERK1 and ERK2 cascade amylin receptor signaling pathway response to amyloid-beta positive regulation of calcium ion import across plasma membrane Sources:Amigo / QuickGO
Orthologs Species Human Mouse Entrez 799 12311 Ensembl ENSG00000004948 ENSMUSG00000023964 UniProt P30988 Q60755 RefSeq (mRNA) NM_001742 NM_001164737 NM_001164738 NM_001042725 NM_007588 NM_001355192 NM_001377018 RefSeq (protein) NP_001158209 NP_001158210 NP_001733 NP_001036190 NP_031614 NP_001342121 NP_001363947 Location (UCSC) Chr 7: 93.42 – 93.57 Mb Chr 6: 3.69 – 3.76 Mb PubMed search [3] [4]
Wikidata
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CT works by activating the G-proteins G_s and G_q often found on osteoclasts, on cells in the kidney, and on cells in a number of regions of the brain.^[9] It may also affect the ovaries in women and the testes in men.

The function of the CT receptor protein is modified through its interaction with Receptor activity-modifying proteins (RAMPs), forming the multimeric amylin receptors AMY₁ (CT + RAMP1), AMY₂ (CT + RAMP2), and AMY₃ (CT+ RAMP3).^[10]

Preclinical studies have suggested that dual amylin and calcitonin receptor agonists may be more effective than amylin receptor agonists for obesity and type II diabetes.^[11]

Interactions

Structure of human calcitonin recptor-G_s complex. The transmembrane calcitonin receptor (blue) is bound to human calcitonin (red) and the G_s complex (yellow). PDB: 7TYO​

Calcitonin receptor has been shown to interact with Apolipoprotein B^[12][13] and LRP1.^[14]