CAMK1

Calcium/calmodulin-dependent protein kinase type 1 is an enzyme that in humans is encoded by the CAMK1 gene.^[5][6]

CAMK1
Available structures PDB Ortholog search: PDBe RCSB List of PDB id codes 4FG7, 4FG8, 4FG9, 4FGB
Identifiers
Aliases	CAMK1, CAMKI, calcium/calmodulin dependent protein kinase I, CaMKI-alpha, CaM kinase I alpha
External IDs	OMIM: 604998; MGI: 1098535; HomoloGene: 117458; GeneCards: CAMK1; OMA:CAMK1 - orthologs
Gene location (Human) Chr. Chromosome 3 (human)[1] Band 3p25.3 Start 9,757,347 bp[1] End 9,769,992 bp[1]
Gene location (Mouse) Chr. Chromosome 6 (mouse)[2] Band 6 E3|6 52.75 cM Start 113,311,085 bp[2] End 113,320,945 bp[2]
RNA expression pattern Bgee Human Mouse (ortholog) Top expressed in right adrenal cortex left adrenal cortex right frontal lobe nucleus accumbens prefrontal cortex caudate nucleus monocyte amygdala left uterine tube putamen Top expressed in superior frontal gyrus stroma of bone marrow primary visual cortex external carotid artery dorsomedial hypothalamic nucleus internal carotid artery right kidney arcuate nucleus myocardium of ventricle dentate gyrus of hippocampal formation granule cell More reference expression data BioGPS More reference expression data
Gene ontology Molecular function transferase activity nucleotide binding protein kinase activity kinase activity protein serine/threonine kinase activity protein binding catalytic activity ATP binding calmodulin-dependent protein kinase activity calmodulin binding Cellular component cytoplasm nucleus intracellular anatomical structure postsynaptic density glutamatergic synapse cytosol Biological process cell differentiation positive regulation of synapse structural plasticity positive regulation of muscle cell differentiation regulation of muscle cell differentiation phosphorylation positive regulation of syncytium formation by plasma membrane fusion regulation of histone H3-K9 acetylation negative regulation of protein binding positive regulation of dendritic spine development nervous system development positive regulation of peptidyl-serine phosphorylation positive regulation of protein serine/threonine kinase activity positive regulation of protein acetylation regulation of protein localization positive regulation of protein export from nucleus multicellular organism development protein phosphorylation nucleocytoplasmic transport positive regulation of neuron projection development cell cycle metabolism regulation of protein binding positive regulation of transcription by RNA polymerase II signal transduction peptidyl-threonine phosphorylation intracellular signal transduction regulation of synapse organization Sources:Amigo / QuickGO
Orthologs Species Human Mouse Entrez 8536 52163 Ensembl ENSG00000134072 ENSMUSG00000030272 UniProt Q14012 Q91YS8 RefSeq (mRNA) NM_003656 NM_133926 RefSeq (protein) NP_003647 NP_003647.1 NP_598687 Location (UCSC) Chr 3: 9.76 – 9.77 Mb Chr 6: 113.31 – 113.32 Mb PubMed search [3] [4]
Wikidata
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Calcium/calmodulin-dependent protein kinase I is expressed in many tissues and is a component of a calmodulin-dependent protein kinase cascade. Calcium/calmodulin directly activates calcium/calmodulin-dependent protein kinase I by binding to the enzyme and indirectly promotes the phosphorylation and synergistic activation of the enzyme by calcium/calmodulin-dependent protein kinase I kinase.^[6]