CAMK2G

Calcium/calmodulin-dependent protein kinase type II gamma chain is an enzyme that in humans is encoded by the CAMK2G gene.^[5]

CAMK2G
Available structures PDB Ortholog search: PDBe RCSB List of PDB id codes 2UX0, 2V7O
Identifiers
Aliases	CAMK2G, CAMK, CAMK-II, CAMKG, calcium/calmodulin dependent protein kinase II gamma
External IDs	OMIM: 602123; MGI: 88259; HomoloGene: 15596; GeneCards: CAMK2G; OMA:CAMK2G - orthologs
Gene location (Human) Chr. Chromosome 10 (human)[1] Band 10q22.2 Start 73,812,501 bp[1] End 73,874,591 bp[1]
Gene location (Mouse) Chr. Chromosome 14 (mouse)[2] Band 14|14 A3 Start 20,734,875 bp[2] End 20,794,088 bp[2]
RNA expression pattern Bgee Human Mouse (ortholog) Top expressed in frontal pole postcentral gyrus right frontal lobe popliteal artery tibial arteries Brodmann area 10 muscle layer of sigmoid colon right coronary artery lateral nuclear group of thalamus primary visual cortex Top expressed in zygote primary visual cortex superior frontal gyrus dentate gyrus of hippocampal formation granule cell secondary oocyte central gray substance of midbrain muscle of thigh triceps brachii muscle primary motor cortex pontine nuclei More reference expression data BioGPS More reference expression data
Gene ontology Molecular function transferase activity nucleotide binding protein kinase activity protein homodimerization activity kinase activity protein binding calcium-dependent protein serine/threonine phosphatase activity ATP binding protein serine/threonine kinase activity calmodulin-dependent protein kinase activity calmodulin binding identical protein binding Cellular component endocytic vesicle membrane cytosol membrane plasma membrane nucleoplasm sarcoplasmic reticulum sarcoplasmic reticulum membrane cytoplasm postsynaptic density neuron projection Biological process regulation of calcium ion transport phosphorylation interferon-gamma-mediated signaling pathway G1 phase regulation of relaxation of cardiac muscle insulin secretion MAPK cascade multicellular organism development protein phosphorylation protein complex oligomerization regulation of cellular response to heat protein autophosphorylation regulation of skeletal muscle adaptation calcium ion transport protein dephosphorylation nervous system development peptidyl-serine phosphorylation peptidyl-threonine phosphorylation cell differentiation intracellular signal transduction regulation of molecular function Sources:Amigo / QuickGO
Orthologs Species Human Mouse Entrez 818 12325 Ensembl ENSG00000148660 ENSMUSG00000021820 UniProt Q13555 Q923T9 RefSeq (mRNA) NM_001204492 NM_001222 NM_172169 NM_172170 NM_172171 NM_172172 NM_172173 NM_001320898 NM_001039138 NM_001039139 NM_178597 NM_001360186 RefSeq (protein) NP_001191421 NP_001213 NP_001307827 NP_751909 NP_751910 NP_751911 NP_751913 NP_001354443 NP_001354445 NP_001354446 NP_001354447 NP_001354448 NP_001354449 NP_001354450 NP_001354451 NP_001354452 NP_001354453 NP_001354454 NP_001354455 NP_001354456 NP_001354457 NP_001354458 NP_001354459 NP_001354460 NP_001354461 NP_001354462 NP_001354463 NP_001354464 NP_001354465 NP_001354466 NP_001354467 NP_001354468 NP_001354469 NP_001354470 NP_001354471 NP_001354472 NP_001354473 NP_001354474 NP_001354475 NP_001354476 NP_001354477 NP_001034227 NP_001034228 NP_848712 NP_001347115 Location (UCSC) Chr 10: 73.81 – 73.87 Mb Chr 14: 20.73 – 20.79 Mb PubMed search [3] [4]
Wikidata
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Function

The product of this gene belongs to the Serine/Threonine protein kinase family, and to the Ca(2+)/calmodulin-dependent protein kinase subfamily. Calcium signaling is crucial for several aspects of plasticity at glutamatergic synapses. In mammalian cells the enzyme is composed of four different chains: alpha, beta, gamma, and delta. The product of this gene is a gamma chain. Six alternatively spliced variants that encode six different isoforms have been characterized to date. Additional alternative splice variants that encode different isoforms have been described, but their full-length nature has not been determined.^[6]

Interactions

CAMK2G has been shown to interact with RRAD.^[7]

See also

• Ca2+/calmodulin-dependent protein kinase