Calpain-1 catalytic subunit

Calpain-1 catalytic subunit (CANP 1) is a protein that in humans is encoded by the CAPN1 gene.^[5][6][7]

CAPN1
Available structures PDB Ortholog search: PDBe RCSB List of PDB id codes 1ZCM, 2ARY
Identifiers
Aliases	CAPN1, CANP, CANP1, CANPL1, muCANP, muCL, SPG76, calpain 1
External IDs	OMIM: 114220; MGI: 88263; HomoloGene: 3800; GeneCards: CAPN1; OMA:CAPN1 - orthologs
Gene location (Human) Chr. Chromosome 11 (human)[1] Band 11q13.1 Start 65,180,566 bp[1] End 65,212,006 bp[1]
Gene location (Mouse) Chr. Chromosome 19 (mouse)[2] Band 19 A|19 4.34 cM Start 6,038,573 bp[2] End 6,065,927 bp[2]
RNA expression pattern Bgee Human Mouse (ortholog) Top expressed in mucosa of transverse colon skin of leg skin of abdomen minor salivary glands right uterine tube right lobe of thyroid gland olfactory zone of nasal mucosa left lobe of thyroid gland gallbladder ectocervix Top expressed in granulocyte lip transitional epithelium of urinary bladder esophagus muscle of thigh corneal stroma lumbar spinal ganglion ankle triceps brachii muscle knee joint More reference expression data BioGPS More reference expression data
Gene ontology Molecular function cysteine-type peptidase activity metal ion binding peptidase activity protein binding hydrolase activity endopeptidase activity calcium ion binding calcium-dependent cysteine-type endopeptidase activity Cellular component membrane focal adhesion intracellular anatomical structure mitochondrion lysosome extracellular exosome cytosol extracellular region cytoplasm plasma membrane ficolin-1-rich granule lumen Biological process extracellular matrix disassembly receptor catabolic process positive regulation of cell population proliferation regulation of macroautophagy mammary gland involution neutrophil degranulation regulation of catalytic activity cornification self proteolysis proteolysis regulation of NMDA receptor activity Sources:Amigo / QuickGO
Orthologs Species Human Mouse Entrez 823 12333 Ensembl ENSG00000014216 ENSMUSG00000024942 UniProt P07384 O35350 RefSeq (mRNA) NM_001198868 NM_001198869 NM_005186 NM_001110504 NM_007600 RefSeq (protein) NP_001185797 NP_001185798 NP_005177 NP_001103974 NP_031626 Location (UCSC) Chr 11: 65.18 – 65.21 Mb Chr 19: 6.04 – 6.07 Mb PubMed search [3] [4]
Wikidata
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Function

The calpains, calcium-activated neutral proteases, are nonlysosomal, intracellular cysteine proteases. The mammalian calpains include ubiquitous, stomach-specific, and muscle-specific proteins. The ubiquitous enzymes consist of heterodimers with distinct large, catalytic subunits associated with a common small, regulatory subunit. This gene encodes the large subunit of the ubiquitous enzyme, calpain 1.^[7]

Interactions

CAPN1 has been shown to interact with PSEN2.^[8]