Calpain-2 catalytic subunit

Calpain-2 catalytic subunit is a protein that in humans is encoded by the CAPN2 gene.^[5][6]

CAPN2
Available structures PDB Ortholog search: PDBe RCSB List of PDB id codes 1KFU, 1KFX, 2NQA
Identifiers
Aliases	CAPN2, CANP2, CANPL2, CANPml, mCANP, calpain 2
External IDs	OMIM: 114230; MGI: 88264; HomoloGene: 1326; GeneCards: CAPN2; OMA:CAPN2 - orthologs
Gene location (Human) Chr. Chromosome 1 (human)[1] Band 1q41 Start 223,701,593 bp[1] End 223,776,018 bp[1]
Gene location (Mouse) Chr. Chromosome 1 (mouse)[2] Band 1|1 H5 Start 182,294,825 bp[2] End 182,345,173 bp[2]
RNA expression pattern Bgee Human Mouse (ortholog) Top expressed in bronchial epithelial cell nasal epithelium glomerulus mucosa of sigmoid colon right uterine tube parotid gland metanephric glomerulus parietal pleura cartilage tissue visceral pleura Top expressed in endothelial cell of lymphatic vessel genital tubercle facial motor nucleus gastrula umbilical cord left lung tail of embryo right lung right lung lobe cornea More reference expression data BioGPS More reference expression data
Gene ontology Molecular function calcium ion binding cysteine-type peptidase activity metal ion binding cytoskeletal protein binding peptidase activity protein binding protein heterodimerization activity hydrolase activity calcium-dependent cysteine-type endopeptidase activity enzyme binding Cellular component Golgi apparatus pseudopodium membrane focal adhesion perinuclear endoplasmic reticulum intracellular anatomical structure dendrite endoplasmic reticulum cortical actin cytoskeleton membrane raft chromatin lysosome extracellular exosome nucleus cytosol cytoplasm plasma membrane mitochondrial intermembrane space external side of plasma membrane cell projection soma Biological process response to hypoxia protein autoprocessing proteolysis cellular response to amino acid stimulus myoblast fusion proteolysis involved in cellular protein catabolic process regulation of cytoskeleton organization blastocyst development extracellular matrix disassembly female pregnancy positive regulation of cardiac muscle cell apoptotic process regulation of interleukin-6 production cellular response to interferon-beta response to hydrogen peroxide behavioral response to pain cellular response to lipopolysaccharide positive regulation of neuron death positive regulation of myoblast fusion positive regulation of phosphatidylcholine biosynthetic process Sources:Amigo / QuickGO
Orthologs Species Human Mouse Entrez 824 12334 Ensembl ENSG00000162909 ENSMUSG00000026509 UniProt P17655 O08529 RefSeq (mRNA) NM_001146068 NM_001748 NM_009794 RefSeq (protein) NP_001139540 NP_001739 NP_033924 Location (UCSC) Chr 1: 223.7 – 223.78 Mb Chr 1: 182.29 – 182.35 Mb PubMed search [3] [4]
Wikidata
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Function

The calpains, calcium-activated neutral proteases, are nonlysosomal, intracellular cysteine proteases. The mammalian calpains include ubiquitous, stomach-specific, and muscle-specific proteins. The ubiquitous enzymes consist of heterodimers with distinct large, catalytic subunits associated with a common small, regulatory subunit. This gene encodes the large subunit of the ubiquitous enzyme, calpain 2. Multiple heterogeneous transcriptional start sites in the 5' UTR have been reported.^[7]

Interactions

CAPN2 has been shown to interact with Bcl-2.^[8]