Calpain-9

Calpain-9 is a protein that in humans is encoded by the CAPN9 gene.^[5][6][7]

CAPN9
Available structures PDB Ortholog search: PDBe RCSB List of PDB id codes 1ZIV, 2P0R
Identifiers
Aliases	CAPN9, GC36, nCL-4, calpain 9
External IDs	OMIM: 606401; MGI: 1920897; HomoloGene: 38208; GeneCards: CAPN9; OMA:CAPN9 - orthologs
Gene location (Human) Chr. Chromosome 1 (human)[1] Band 1q42.2 Start 230,747,384 bp[1] End 230,802,003 bp[1]
Gene location (Mouse) Chr. Chromosome 8 (mouse)[2] Band 8|8 E2 Start 125,302,850 bp[2] End 125,345,470 bp[2]
RNA expression pattern Bgee Human Mouse (ortholog) Top expressed in C1 segment rectum mucosa of transverse colon body of stomach gastric mucosa mucosa of ileum olfactory zone of nasal mucosa bronchial epithelial cell pancreatic ductal cell right lung Top expressed in pyloric antrum epithelium of stomach mucous cell of stomach lumbar spinal ganglion embryo duodenum left colon jejunum intestinal villus morula More reference expression data BioGPS More reference expression data
Gene ontology Molecular function calcium ion binding peptidase activity cysteine-type peptidase activity hydrolase activity metal ion binding calcium-dependent cysteine-type endopeptidase activity Cellular component intracellular anatomical structure cytoplasm cellular component Biological process digestion proteolysis sarcomere organization Sources:Amigo / QuickGO
Orthologs Species Human Mouse Entrez 10753 73647 Ensembl ENSG00000135773 ENSMUSG00000031981 UniProt O14815 Q9D805 RefSeq (mRNA) NM_006615 NM_016452 NM_001319676 NM_023709 RefSeq (protein) NP_001306605 NP_006606 NP_057536 NP_076198 Location (UCSC) Chr 1: 230.75 – 230.8 Mb Chr 8: 125.3 – 125.35 Mb PubMed search [3] [4]
Wikidata
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Calpains are ubiquitous, well-conserved family of calcium-dependent, cysteine proteases. The calpain proteins are heterodimers consisting of an invariant small subunit and variable large subunits. The large subunit possesses a cysteine protease domain, and both subunits possess calcium-binding domains. Calpains have been implicated in neurodegenerative processes, as their activation can be triggered by calcium influx and oxidative stress. The protein encoded by this gene is expressed predominantly in stomach and small intestine and may have specialized functions in the digestive tract. This gene is thought to be associated with gastric cancer. Multiple alternatively spliced transcript variants encoding different isoforms have been found for this gene.^[7]