Capping protein (actin filament) muscle Z-line, alpha 1

F-actin-capping protein subunit alpha-1 is a protein that in humans is encoded by the CAPZA1 gene.^[5][6][7]

CAPZA1
Available structures PDB Ortholog search: PDBe RCSB List of PDB id codes 1MQ1, 1MWN
Identifiers
Aliases	CAPZA1, CAPPA1, CAPZ, CAZ1, capping actin protein of muscle Z-line alpha subunit 1, capping actin protein of muscle Z-line subunit alpha 1
External IDs	OMIM: 601580; MGI: 106227; HomoloGene: 24376; GeneCards: CAPZA1; OMA:CAPZA1 - orthologs
Gene location (Human) Chr. Chromosome 1 (human)[1] Band 1p13.2 Start 112,619,805 bp[1] End 112,671,616 bp[1]
Gene location (Mouse) Chr. Chromosome 3 (mouse)[2] Band 3 F2.2|3 45.88 cM Start 104,730,095 bp[2] End 104,771,821 bp[2]
RNA expression pattern Bgee Human Mouse (ortholog) Top expressed in epithelium of nasopharynx gingival epithelium bone marrow germinal epithelium mucosa of pharynx monocyte trabecular bone skin of thigh oral cavity bone marrow cell Top expressed in granulocyte tail of embryo thymus spermatocyte yolk sac genital tubercle ventricular zone ileum stomach neural tube More reference expression data BioGPS n/a
Gene ontology Molecular function actin binding protein binding cadherin binding actin filament binding Cellular component F-actin capping protein complex cytoplasm extracellular region cytosol WASH complex extracellular exosome cytoskeleton actin cytoskeleton actin cortical patch Biological process barbed-end actin filament capping innate immune response blood coagulation actin filament capping endoplasmic reticulum to Golgi vesicle-mediated transport antigen processing and presentation of exogenous peptide antigen via MHC class II interleukin-12-mediated signaling pathway cell junction assembly actin cytoskeleton organization protein-containing complex assembly Sources:Amigo / QuickGO
Orthologs Species Human Mouse Entrez 829 12340 Ensembl ENSG00000116489 ENSMUSG00000070372 UniProt P52907 P47753 RefSeq (mRNA) NM_006135 NM_009797 NM_001355044 RefSeq (protein) NP_006126 NP_033927 NP_001341973 Location (UCSC) Chr 1: 112.62 – 112.67 Mb Chr 3: 104.73 – 104.77 Mb PubMed search [3] [4]
Wikidata
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CAPZA1 is a member of the F-actin capping protein alpha subunit family. This gene encodes the alpha subunit of the barbed-end actin binding protein.

Function

The protein regulates growth of the actin filament by capping the barbed end (plus-end) of growing actin filaments, preventing any further assembly from occurring.^[7] This protein can be bound to the lipid PIP2 preventing it from binding to actin filaments.