Caspase 7

Caspase-7, apoptosis-related cysteine peptidase, also known as CASP7, is a human protein encoded by the CASP7 gene. CASP7 orthologs^[5] have been identified in nearly all mammals for which complete genome data are available. Unique orthologs are also present in birds, lizards, lissamphibians, and teleosts.

CASP7
Available structures PDB Ortholog search: PDBe RCSB List of PDB id codes 1F1J, 1GQF, 1I4O, 1I51, 1K86, 1K88, 1KMC, 1SHJ, 1SHL, 2QL5, 2QL7, 2QL9, 2QLB, 2QLF, 2QLJ, 3EDR, 3H1P, 3IBC, 3IBF, 3R5K, 4FDL, 4FEA, 4HQ0, 4HQR, 4JB8, 4JJ8, 4JR1, 4JR2, 4LSZ, 4ZVR, 4ZVQ, 4ZVO, 4ZVU, 4ZVT, 4ZVS, 4ZVP, 5IC6
Identifiers
Aliases	CASP7, CASP-7, CMH-1, ICE-LAP3, LICE2, MCH3, Caspase 7
External IDs	OMIM: 601761; MGI: 109383; HomoloGene: 11168; GeneCards: CASP7; OMA:CASP7 - orthologs
Gene location (Human) Chr. Chromosome 10 (human)[1] Band 10q25.3 Start 113,679,162 bp[1] End 113,730,907 bp[1]
Gene location (Mouse) Chr. Chromosome 19 (mouse)[2] Band 19 D2|19 51.84 cM Start 56,385,561 bp[2] End 56,430,776 bp[2]
RNA expression pattern Bgee Human Mouse (ortholog) Top expressed in rectum palpebral conjunctiva epithelium of nasopharynx jejunal mucosa mucosa of transverse colon duodenum parotid gland nasal epithelium mucosa of sigmoid colon mucosa of paranasal sinus Top expressed in intestinal villus Ileal epithelium jejunum lens left colon duodenum submandibular gland pineal gland conjunctival fornix choroidal fissure More reference expression data BioGPS More reference expression data
Gene ontology Molecular function cysteine-type peptidase activity cysteine-type endopeptidase activity protein binding hydrolase activity peptidase activity cysteine-type endopeptidase activity involved in execution phase of apoptosis cysteine-type endopeptidase activity involved in apoptotic process Cellular component cytoplasm cytosol nucleus nucleoplasm Biological process proteolysis cellular response to staurosporine execution phase of apoptosis apoptotic process Sources:Amigo / QuickGO
Orthologs Species Human Mouse Entrez 840 12369 Ensembl ENSG00000165806 ENSMUSG00000025076 UniProt P55210 P97864 RefSeq (mRNA) NM_001227 NM_001267056 NM_001267057 NM_001267058 NM_033338 NM_033339 NM_033340 NM_001320911 NM_007611 RefSeq (protein) NP_001218 NP_001253985 NP_001253986 NP_001253987 NP_001307840 NP_203124 NP_203125 NP_203126 NP_031637 Location (UCSC) Chr 10: 113.68 – 113.73 Mb Chr 19: 56.39 – 56.43 Mb PubMed search [3] [4]
Wikidata
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Function

Caspase-7 is a member of the caspase (cysteine aspartate protease) family of proteins, and has been shown to be an executioner protein of apoptosis. Sequential activation of caspases plays a central role in the execution-phase of cell apoptosis. Caspases exist as inactive proenzymes that undergo proteolytic processing by upstream caspases (caspase-8, -9) at conserved aspartic residues to produce two subunits, large and small, that dimerize to form the active enzyme in the form of a heterotetramer. The precursor of this caspase is cleaved by caspase 3, caspase 10, and caspase 9. It is activated upon cell death stimuli and induces apoptosis. Alternative splicing results in four transcript variants, encoding three distinct isoforms.^[6]

Interactions

Caspase 7 has been shown to interact with:

• Caspase 8,^[7][8]
• Survivin^[9][10] and
• XIAP.^{[11][12][13][14]}

See also

• The Proteolysis Map
• Caspase