CatSper1

CatSper1, is a protein which in humans is encoded by the CATSPER1 gene.^[5][6][7] CatSper1 is a member of the cation channels of sperm family of protein. The four proteins in this family together form a Ca²⁺-permeant ion channel specific essential for the correct function of sperm cells.^[8]

CATSPER1
Identifiers
Aliases	CATSPER1, CATSPER, SPGF7, CatSper1, cation channel sperm associated 1
External IDs	OMIM: 606389; MGI: 2179947; HomoloGene: 14207; GeneCards: CATSPER1; OMA:CATSPER1 - orthologs
Gene location (Human) Chr. Chromosome 11 (human)[1] Band 11q13.1 Start 66,016,752 bp[1] End 66,026,479 bp[1]
Gene location (Mouse) Chr. Chromosome 19 (mouse)[2] Band 19|19 A Start 5,385,769 bp[2] End 5,394,308 bp[2]
RNA expression pattern Bgee Human Mouse (ortholog) Top expressed in testicle monocyte granulocyte left testis right testis Descending thoracic aorta ascending aorta blood popliteal artery tibial arteries Top expressed in seminiferous tubule spermatid spermatocyte islet of Langerhans More reference expression data BioGPS n/a
Gene ontology Molecular function calcium activated cation channel activity calcium channel activity voltage-gated ion channel activity ion channel activity protein binding high voltage-gated calcium channel activity voltage-gated calcium channel activity Cellular component integral component of membrane CatSper complex cell projection membrane plasma membrane cilium motile cilium Biological process cell differentiation membrane depolarization during action potential regulation of ion transmembrane transport ion transport multicellular organism development calcium ion transmembrane transport transmembrane transport spermatogenesis sperm-egg recognition calcium ion transport flagellated sperm motility regulation of cilium beat frequency involved in ciliary motility response to progesterone Sources:Amigo / QuickGO
Orthologs Species Human Mouse Entrez 117144 225865 Ensembl ENSG00000175294 ENSMUSG00000038498 UniProt Q8NEC5 Q91ZR5 RefSeq (mRNA) NM_053054 NM_139301 RefSeq (protein) NP_444282 NP_647462 Location (UCSC) Chr 11: 66.02 – 66.03 Mb Chr 19: 5.39 – 5.39 Mb PubMed search [3] [4]
Wikidata
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Function

Calcium ions play a primary role in the regulation of sperm motility. This gene belongs to a family of putative cation channels that are specific to spermatozoa and localize to the flagellum. The protein family features a single repeat with six membrane-spanning segments and a predicted calcium-selective pore region.^[9]