Caveolin 2

Not to be confused with 2CAV, the 2nd Cavalry (disambiguation)

For the ICAO coded Hope (Fraser Canyon Hospital) Heliport, see Hope, British Columbia.

Caveolin-2 is a protein that in humans is encoded by the CAV2 gene.^[5][6][7]

CAV2
Identifiers
Aliases	CAV2, CAV, caveolin 2
External IDs	OMIM: 601048; MGI: 107571; HomoloGene: 942; GeneCards: CAV2; OMA:CAV2 - orthologs
Gene location (Human) Chr. Chromosome 7 (human)[1] Band 7q31.2 Start 116,287,380 bp[1] End 116,508,541 bp[1]
Gene location (Mouse) Chr. Chromosome 6 (mouse)[2] Band 6|6 A2 Start 17,281,184 bp[2] End 17,289,114 bp[2]
RNA expression pattern Bgee Human Mouse (ortholog) Top expressed in lower lobe of lung right ventricle vena cava myocardium urethra synovial joint parietal pleura skin of hip adipose tissue right coronary artery Top expressed in left lung left lung lobe white adipose tissue sciatic nerve right lung right lung lobe brown adipose tissue mammary gland seminal vesicula tunica adventitia of aorta More reference expression data BioGPS More reference expression data
Gene ontology Molecular function protein-macromolecule adaptor activity protein homodimerization activity scaffold protein binding protein binding protein heterodimerization activity molecular adaptor activity D1 dopamine receptor binding protein kinase binding structural molecule activity Cellular component cytoplasm Golgi apparatus membrane focal adhesion extrinsic component of cytoplasmic side of plasma membrane Golgi membrane plasma membrane integral component of plasma membrane intracellular anatomical structure transport vesicle acrosomal membrane perinuclear region of cytoplasm caveola membrane raft cytoplasmic vesicle nucleus protein-containing complex sarcolemma Biological process insulin receptor signaling pathway positive regulation of endothelial cell proliferation caveola assembly vesicle organization mitochondrion organization negative regulation of transforming growth factor beta receptor signaling pathway positive regulation of dopamine receptor signaling pathway endoplasmic reticulum organization negative regulation of endothelial cell proliferation vesicle docking positive regulation of GTPase activity positive regulation by host of viral process skeletal muscle fiber development protein complex oligomerization receptor-mediated endocytosis of virus by host cell vesicle fusion positive regulation of MAPK cascade regulation of mitotic nuclear division negative regulation of cell population proliferation cell differentiation Sources:Amigo / QuickGO
Orthologs Species Human Mouse Entrez 858 12390 Ensembl ENSG00000105971 ENSMUSG00000000058 UniProt P51636 Q9WVC3 RefSeq (mRNA) NM_001206747 NM_001206748 NM_001233 NM_198212 NM_001277756 NM_016900 RefSeq (protein) NP_001193676 NP_001193677 NP_001224 NP_937855 NP_001264685 NP_058596 Location (UCSC) Chr 7: 116.29 – 116.51 Mb Chr 6: 17.28 – 17.29 Mb PubMed search [3] [4]
Wikidata
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The protein encoded by this gene is a major component of the inner surface of caveolae, small invaginations of the plasma membrane, and is involved in essential cellular functions, including signal transduction, lipid metabolism, cellular growth control and apoptosis. This protein may function as a tumor suppressor. The CAV1 and CAV2 genes are located next to each other on chromosome 7 and express colocalizing proteins that form a stable hetero-oligomeric complex,^[7][8] which can be disrupted by Src-mediated phosphorylation of tyrosine 19 on caveolin-2.^[9] Two transcript variants encoding distinct isoforms have been identified for this gene. By using alternative initiation codons in the same reading frame, two isoforms (alpha and beta) are encoded by one transcript.^[7]

Interactions

Caveolin 2 has been shown to interact with Caveolin 1^[8][10] and RAS p21 protein activator 1.^[9]