CCL24

Chemokine (C-C motif) ligand 24 (CCL24) also known as myeloid progenitor inhibitory factor 2 (MPIF-2) or eosinophil chemotactic protein 2 (eotaxin-2) is a protein that in humans is encoded by the CCL24 gene.^[1] This gene is located on human chromosome 7.^[2]

chemokine (C-C motif) ligand 24
Identifiers
Symbol	CCL24
Alt. symbols	SCYA24, Ckb-6, MPIF-2, eotaxin-2
NCBI gene	6369
HGNC	10623
OMIM	602495
PDB	1EIG
RefSeq	NM_002991
UniProt	O00175
Other data
Locus	Chr. 7 q11.23
Search for Structures Swiss-model Domains InterPro

Function

CCL24 is a small cytokine belonging to the CC chemokine family. CCL24 interacts with chemokine receptor CCR3 to induce chemotaxis in eosinophils.^[3] This chemokine is also strongly chemotactic for resting T lymphocytes and slightly chemotactic for neutrophils.^[1]

Clinical significance

Elevated levels of eotaxin-2 has been seen in patients with aspirin-exacerbated respiratory disease (AERD), such as asthma. People with lower plasma levels of eotaxin-2 have not been showing tendency to develop aspirin inducible asthma.^[4]