C-C motif chemokine ligand 27

C-C motif chemokine ligand 27 is a protein that in humans is encoded by the CCL27 gene. ^[5]

CCL27
Available structures PDB Ortholog search: PDBe RCSB List of PDB id codes 2KUM
Identifiers
Aliases	CCL27, ALP, CTACK, CTAK, ESKINE, ILC, PESKY, SCYA27, C-C motif chemokine ligand 27
External IDs	OMIM: 604833; MGI: 1891389; HomoloGene: 104838; GeneCards: CCL27; OMA:CCL27 - orthologs
Gene location (Human) Chr. Chromosome 9 (human)[1] Band 9p13.3 Start 34,661,880 bp[1] End 34,664,048 bp[1]
Gene location (Mouse) Chr. Chromosome 4 (mouse)[2] Band 4 A5|4 Start 42,655,251 bp[2] End 42,656,005 bp[2]
RNA expression pattern Bgee Human Mouse (ortholog) Top expressed in skin of abdomen skin of leg testicle gonad stromal cell of endometrium ganglionic eminence ventricular zone primary visual cortex left testis skeletal muscle tissue Top expressed in zone of skin pelvic ganglion lip placenta spermatocyte urethra female urethra adrenal gland male urethra thymus More reference expression data BioGPS n/a
Gene ontology Molecular function chemokine activity cytokine activity CCR3 chemokine receptor binding protein binding Cellular component extracellular region extracellular space Biological process chemotaxis cell-cell signaling immune response cell chemotaxis antimicrobial humoral immune response mediated by antimicrobial peptide regulation of signaling receptor activity G protein-coupled receptor signaling pathway positive regulation of T cell chemotaxis positive regulation of mononuclear cell migration positive regulation of actin cytoskeleton reorganization Sources:Amigo / QuickGO
Orthologs Species Human Mouse Entrez 10850 100040048 Ensembl ENSG00000213927 ENSMUSG00000096826 UniProt Q9Y4X3 Q9Z1X0 RefSeq (mRNA) NM_006664 NM_001199959 NM_001199960 NM_001199961 RefSeq (protein) NP_006655 NP_001041644 NP_001157516 NP_001157517 NP_001333994 NP_001348175 NP_035466 Location (UCSC) Chr 9: 34.66 – 34.66 Mb Chr 4: 42.66 – 42.66 Mb PubMed search [3] [4]
Wikidata
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chemokine (C-C motif) ligand 27
Identifiers
Symbol	CCL27
Alt. symbols	SCYA27, ALP, ILC, CTACK, skinkine, ESkine, PESKY, CTAK
NCBI gene	10850
HGNC	10626
OMIM	604833
RefSeq	NM_006664
UniProt	Q9Y4X3
Other data
Locus	Chr. 9 q13
Search for Structures Swiss-model Domains InterPro

Function

This gene is one of several CC cytokine genes clustered on the p-arm of chromosome 9. Cytokines are a family of secreted proteins involved in immunoregulatory and inflammatory processes. The CC cytokines are proteins characterized by two adjacent cysteines. The protein encoded by this gene is chemotactic for skin-associated memory T lymphocytes. CCL27 is associated with homing of memory T lymphocytes to the skin, and plays a role in T cell-mediated inflammation of the skin.^[6][7] CCL27 is expressed in numerous tissues, including gonads, thymus, placenta and skin. It elicits its chemotactic effects by binding to the chemokine receptor CCR10.^[8] The gene for CCL27 is located on human chromosome 9.^[9] Studies of a similar murine protein indicate that these protein-receptor interactions have a pivotal role in T cell-mediated skin inflammation. [provided by RefSeq, Sep 2014].