CCL4L1

C-C motif chemokine 4-like is a protein that in humans is encoded by the CCL4L1 gene.^[2][3][4][5]

CCL4L1
Identifiers
Aliases	CCL4L1, AT744.2, CCL4L, LAG-1, LAG1, SCYA4L, SCYA4L1, MIP-1-beta, SCYA4L2, C-C motif chemokine ligand 4 like 1
External IDs	OMIM: 603782; GeneCards: CCL4L1; OMA:CCL4L1 - orthologs
Gene ontology Molecular function chemokine activity cytokine activity protein binding CCR chemokine receptor binding Cellular component extracellular region extracellular space Biological process lymphocyte chemotaxis chemokine-mediated signaling pathway cellular response to tumor necrosis factor G protein-coupled receptor signaling pathway positive regulation of GTPase activity chemotaxis inflammatory response cellular response to interleukin-1 monocyte chemotaxis neutrophil chemotaxis immune response positive regulation of ERK1 and ERK2 cascade cellular response to interferon-gamma regulation of signaling receptor activity eosinophil chemotaxis Sources:Amigo / QuickGO
Orthologs Species Human Mouse Entrez 388372 n/a Ensembl n/a n/a UniProt Q8NHW4 n/a RefSeq (mRNA) NM_207007 n/a RefSeq (protein) NP_996890 n/a Location (UCSC) n/a n/a PubMed search [1] n/a
Wikidata
View/Edit Human

Function

This gene is one of several cytokine genes clustered on the q-arm of chromosome 17. Cytokines are a family of secreted proteins involved in immunoregulatory and inflammatory processes. This protein is similar to CCL4 which inhibits HIV entry by binding to the cellular receptor CCR5. The copy number of this gene varies among individuals; most individuals have 1-5 copies in the diploid genome, although rare individuals do not contain this gene at all. The human genome reference assembly contains two copies of this gene. This record represents the more centromeric gene.^[5]