Cyclin D2

G1/S-specific cyclin-D2 is a protein that in humans is encoded by the CCND2 gene.^[5]

CCND2
Identifiers
Aliases	CCND2, KIAK0002, MPPH3, cyclin D2
External IDs	OMIM: 123833; MGI: 88314; HomoloGene: 37525; GeneCards: CCND2; OMA:CCND2 - orthologs
Gene location (Human) Chr. Chromosome 12 (human)[1] Band 12p13.32 Start 4,269,771 bp[1] End 4,305,353 bp[1]
Gene location (Mouse) Chr. Chromosome 6 (mouse)[2] Band 6 F3|6 61.92 cM Start 127,125,162 bp[2] End 127,152,193 bp[2]
RNA expression pattern Bgee Human Mouse (ortholog) Top expressed in seminal vesicula tail of epididymis ventricular zone ganglionic eminence cardiac muscle tissue of right atrium myocardium of left ventricle corpus epididymis epithelium of colon caput epididymis tendon of biceps brachii Top expressed in Rostral migratory stream calvaria medial ganglionic eminence hand otic placode vas deferens hair follicle maxillary prominence Paneth cell iris More reference expression data BioGPS More reference expression data
Gene ontology Molecular function protein binding protein kinase binding protein kinase activity cyclin-dependent protein serine/threonine kinase regulator activity Cellular component cytoplasm cytosol chromatin cyclin-dependent protein kinase holoenzyme complex nuclear membrane nucleolus membrane nucleus nucleoplasm cyclin D2-CDK4 complex Biological process cell cycle positive regulation of protein phosphorylation positive regulation of cyclin-dependent protein serine/threonine kinase activity regulation of cell cycle cell division positive regulation of cell population proliferation positive regulation of G1/S transition of mitotic cell cycle negative regulation of apoptotic process long-term memory adult locomotory behavior cellular response to X-ray regulation of cyclin-dependent protein serine/threonine kinase activity mitotic cell cycle protein phosphorylation regulation of mitotic nuclear division positive regulation of cell cycle mitotic cell cycle phase transition Sources:Amigo / QuickGO
Orthologs Species Human Mouse Entrez 894 12444 Ensembl ENSG00000118971 ENSMUSG00000000184 UniProt P30279 P30280 RefSeq (mRNA) NM_001759 NM_009829 RefSeq (protein) NP_001750 NP_033959 Location (UCSC) Chr 12: 4.27 – 4.31 Mb Chr 6: 127.13 – 127.15 Mb PubMed search [3] [4]
Wikidata
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Function

The protein encoded by this gene belongs to the highly conserved cyclin family, whose members are characterized by a dramatic periodicity in protein abundance through the cell cycle. Cyclins function as regulators of cyclin-dependent kinases. Different cyclins exhibit distinct expression and degradation patterns which contribute to the temporal coordination of each mitotic event. This cyclin forms a complex with and functions as a regulatory subunit of CDK4 or CDK6, whose activity is required for cell cycle G1/S transition. This protein has been shown to interact with and be involved in the phosphorylation of tumor suppressor protein Rb. Knockout studies of the homologous gene in mouse suggest the essential roles of this gene in ovarian granulosa and germ cell proliferation. High level expression of this gene was observed in ovarian and testicular tumors.^[6]

Clinical significance

Mutations in CCND2 are associated to megalencephaly-polymicrogyria-polydactyly-hydrocephalus syndrome.^[7]