CCR8 (gene)

Chemokine (C-C motif) receptor 8, also known as CCR8, is a protein which in humans is encoded by the CCR8 gene.^[5] CCR8 has also recently been designated CDw198 (cluster of differentiation w198).

CCR8
Identifiers
Aliases	CCR8, CC-CKR-8, CCR-8, CDw198, CKRL1, CMKBR8, CMKBRL2, CY6, GPRCY6, TER1, C-C motif chemokine receptor 8
External IDs	OMIM: 601834; MGI: 1201402; HomoloGene: 21080; GeneCards: CCR8; OMA:CCR8 - orthologs
Gene location (Human) Chr. Chromosome 3 (human)[1] Band 3p22.1 Start 39,329,709 bp[1] End 39,333,680 bp[1]
Gene location (Mouse) Chr. Chromosome 9 (mouse)[2] Band 9|9 F4 Start 119,921,180 bp[2] End 119,923,972 bp[2]
RNA expression pattern Bgee Human Mouse (ortholog) Top expressed in gonad granulocyte appendix gallbladder lymph node blood rectum tonsil urinary bladder spleen Top expressed in morula embryo pharynx thymus meninges lip spleen stomach Thalamus Amygdala More reference expression data BioGPS More reference expression data
Gene ontology Molecular function C-C chemokine receptor activity G protein-coupled receptor activity chemokine receptor activity coreceptor activity signal transducer activity chemokine binding C-C chemokine binding Cellular component integral component of membrane plasma membrane integral component of plasma membrane membrane intracellular anatomical structure external side of plasma membrane Biological process positive regulation of cytosolic calcium ion concentration chemotaxis chemokine-mediated signaling pathway G protein-coupled receptor signaling pathway cell adhesion immune response signal transduction calcium-mediated signaling cell chemotaxis Sources:Amigo / QuickGO
Orthologs Species Human Mouse Entrez 1237 12776 Ensembl ENSG00000179934 ENSMUSG00000042262 UniProt P51685 P56484 RefSeq (mRNA) NM_005201 NM_007720 RefSeq (protein) NP_005192 NP_031746 Location (UCSC) Chr 3: 39.33 – 39.33 Mb Chr 9: 119.92 – 119.92 Mb PubMed search [3] [4]
Wikidata
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Function

This gene encodes a member of the beta chemokine receptor family, which is predicted to be a seven transmembrane protein similar to G protein-coupled receptors. Chemokines and their receptors are important for the migration of various cell types into the inflammatory sites. This receptor protein preferentially expresses in the thymus. The ligand of the CCR8 is CCL1.^[6] CCL8 also functions as a CCR8 agonist.^[7]

Studies of this receptor and its ligands suggested its role in regulation of monocyte chemotaxis and thymic cell apoptosis. More specifically, this receptor may contribute to the proper positioning of activated T cells within the antigenic challenge sites and specialized areas of lymphoid tissues. This gene is located at the chemokine receptor gene cluster region.^[5]

See also

• CC chemokine receptors