CD120

CD120 (Cluster of Differentiation 120) can refer to two members of the tumor necrosis factor receptor superfamily: tumor necrosis factor receptor 1 (TNFR1) and tumor necrosis factor receptor 2 (TNFR2).^[1][2]

tumor necrosis factor receptor superfamily, member 1A
Identifiers
Symbol	TNFRSF1A
Alt. symbols	CD120a, TNFR1
NCBI gene	7132
HGNC	11916
OMIM	191190
RefSeq	NM_001065
UniProt	P19438
Other data
Locus	Chr. 12 p13.2
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tumor necrosis factor receptor superfamily, member 1B
Identifiers
Symbol	TNFRSF1B
Alt. symbols	CD120a, TNFR2
NCBI gene	7133
HGNC	11917
OMIM	191191
RefSeq	NM_001066
UniProt	P20333
Other data
Locus	Chr. 1 p36.22
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Receptor subtypes

There are two variants of the receptor, each encoded by a separate gene:

• CD120a - TNFR1 - TNFR superfamily member 1A
• CD120b - TNFR2 - TNFR superfamily member 1B

TNFR1 is the receptor type responsible for mediation of TNF-alpha induced sickness behavior,^[3] and is involved in neurotoxic processes.^[4] Elevated levels of TNFR1 has been found in severe mental disorders.^[5]

Signaling pathway

Signaling pathway of TNF-R1. Dashed grey lines represent multiple steps

See also

• Cluster of differentiation